DegronMD - Q8N2C7(UNC80)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P2009L	TCGA-AD-6889	COAD	TCGA	LPVHED	LIG_APCC_ABBA_1	2012:2017	Mutation rewiring degron network	0.25
p.A2936V	TCGA-AX-A1CE	UCEC	TCGA	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation altering degron motif	0.5825
p.D1106Y	TCGA-CI-6624	READ	TCGA	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.1111
p.G2002E	TCGA-DX-AB2E	SARC	TCGA	LPVHED	LIG_APCC_ABBA_1	2012:2017	Mutation rewiring degron network	0.0556
p.E3149K	TCGA-EY-A1GI	UCEC	TCGA	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.2778
p.C1768Y	TCGA-F5-6702	READ	TCGA	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation altering degron motif	0.5976
p.R2940S	TCGA-UB-A7MB	LIHC	TCGA	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation rewiring degron network	0.3056
p.R1107Q	DO50505	BOCA	ICGC	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.0833
p.S385C	DO227535	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.7541
p.S3141N	DO52699	CLLE	ICGC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.0556
p.P2004L	DO8463	COAD	ICGC	LPVHED	LIG_APCC_ABBA_1	2012:2017	Mutation rewiring degron network	0.1111
p.M2933R	DO50357	ESAD	ICGC	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation altering degron motif	0.8632
p.S1767P	DO234245	ESAD	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation altering degron motif	0.6752
p.S1103I	DO234277	ESAD	ICGC	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.1944
p.G2920V	DO234293	ESAD	ICGC	VGTST	DEG_SPOP_SBC_1	2924:2928	Mutation rewiring degron network	0.2222
p.V3142M	DO228491	GACA	ICGC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.0833
p.T2013N	DO228580	GACA	ICGC	LPVHED	LIG_APCC_ABBA_1	2012:2017	Mutation altering degron motif	0.7055
p.V2919M	DO233168	GACA	ICGC	VGTST	DEG_SPOP_SBC_1	2924:2928	Mutation rewiring degron network	0.1944
p.V2919M	DND-41	haematopoietic and lymphoid tissue	COSMIC	VGTST	DEG_SPOP_SBC_1	2924:2928	Mutation rewiring degron network	0.1944
p.P371L	DO233261	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0556
p.P371L	SIDM01652	Non-Cancerous	GDSC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0556
p.P371L	SIDM00187	Kidney Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0556
p.T2938M	DO233207	GACA	ICGC	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation altering degron motif	0.7423
p.T1762A	DO233882	GACA	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.2222
p.E2024D	DO228952	LICA	ICGC	LPVHED	LIG_APCC_ABBA_1	2012:2017	Mutation rewiring degron network	0.1389
p.G3155V	DO228974	LICA	ICGC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation altering degron motif	0.7532
p.C1758F	DO229026	LICA	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.1111
p.R2935S	DO52318	LIHC	ICGC	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation altering degron motif	0.7427
p.R2927L	DO50793	LIRI	ICGC	VGTST	DEG_SPOP_SBC_1	2924:2928	Mutation altering degron motif	0.8428
p.P1769L	DO45299	LIRI	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation altering degron motif	0.7582
p.K3145N	DO48701	LIRI	ICGC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.1667
p.P3151L	DO27318	LUSC	ICGC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation altering degron motif	0.7582
p.P391S	DO220877	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1667
p.S3141R	DO50729	ORCA	ICGC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.0556
p.D3160Y	DO36443	READ	ICGC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.1944
p.D1101Y	DO37130	READ	ICGC	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.25
p.C1763Y	DO36633	READ	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.25
p.P1765S	DO234097	THCA	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.3056
p.E3154D	DO42280	UCEC	ICGC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation altering degron motif	0.6758
p.A2931V	DO42280	UCEC	ICGC	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation altering degron motif	0.6936
p.A1780T	DO41211	UCEC	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.1389
p.A1098E	SIDM02012	Colorectal Carcinoma	GDSC	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.659
p.D3162Y	SIDM01126	Small Cell Lung Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.1389
p.D3162Y	NCI-H64	lung	COSMIC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.1389
p.S1108C	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.0556
p.S1108C	ACH-000860	Lung Cancer	CCLE	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.0556
p.S1108C	NCI-H358	lung	COSMIC	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.0556
p.P1770H	SIDM00719	Small Cell Lung Carcinoma	GDSC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation altering degron motif	0.7694
p.P1770H	ACH-001364	Lung Cancer	CCLE	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation altering degron motif	0.7694
p.P1770H	NCI-H345	lung	COSMIC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation altering degron motif	0.7694
p.P1757L	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.0833
p.P1757L	ACH-000894	Lung Cancer	CCLE	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.0833
p.P1757L	NCI-H1869	lung	COSMIC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.0833
p.L377F	SIDM00450	Acute Myeloid Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2222
p.L377F	ACH-000218	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2222
p.L377F	PL-21	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2222
p.P379S	SIDM00683	Prostate Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2778
p.P379S	SIDM00183	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2778
p.P379S	SIDM01648	Non-Cancerous	GDSC	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2778
p.P379S	ACH-000977	lymph node	CCLE	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2778
p.E3145V	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.1667
p.E3145V	ACH-001137	Lung Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.1667
p.E3145V	NCI-H1993	lung	COSMIC	VLTSS	DEG_SPOP_SBC_1	3151:3155	Mutation rewiring degron network	0.1667
p.V2924M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VGTST	DEG_SPOP_SBC_1	2924:2928	Mutation altering degron motif	0.7208
p.V2924M	DND-41	haematopoietic and lymphoid tissue	COSMIC	VGTST	DEG_SPOP_SBC_1	2924:2928	Mutation altering degron motif	0.7208
p.T2945M	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation rewiring degron network	0.1667
p.T2945M	ACH-000282	Lung Cancer	CCLE	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation rewiring degron network	0.1667
p.T2945M	NCI-H1755	lung	COSMIC	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation rewiring degron network	0.1667
p.I1083T	SIDM00316	Glioblastoma	GDSC	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.1389
p.I1083T	ACH-000469	Brain Cancer	CCLE	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.1389
p.I1083T	YH-13	central nervous system	COSMIC	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.1389
p.A2931T	ACH-000455	Brain Cancer	CCLE	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation altering degron motif	0.7139
p.E1779D	ACH-000954	Endometrial/Uterine Cancer	CCLE	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.1667
p.T2013S	ACH-001031	Rhabdoid	CCLE	LPVHED	LIG_APCC_ABBA_1	2012:2017	Mutation altering degron motif	0.7116
p.R380S	ACH-002061	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.3056
p.P1765H	NCI-H345	lung	COSMIC	PTCTPNSE	DEG_SCF_FBW7_2	1766:1773	Mutation rewiring degron network	0.3056
p.T2940M	NCI-H1755	lung	COSMIC	YRLSLATMS	DEG_APCC_DBOX_1	2931:2939	Mutation rewiring degron network	0.3056
p.S1103C	NCI-H358	lung	COSMIC	KRSSLSGLA	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNC80

UniProt ID: Q8N2C7

Entrez ID: 285175

Protein name: Protein unc-80 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNC80 in