DegronMD

Uniprot ID: Q8N2C7

Source protein: Protein unc-80 homolog

Source gene: UNC80

Class: DEG_SCF_FBW7_2

Location: 1766:1773

E3 ligase: FBXW7

DEGRON score: 0.9544

ASA_SCORE: 75.725

COIL: 0.8735

CONS_SCORE: 0.3786

DSS_SCORE: 0.5966

HELIX: 0.0685

FCONS_SCORE: 0.8581

RIG_SCORE: 0.6894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1768Y	TCGA-F5-6702	READ	TCGA	PTCTPNSE	DEG_SCF_FBW7_2	0.5976
p.S1767P	DO234245	ESAD	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	0.6752
p.T1762A	DO233882	GACA	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	0.2222
p.C1758F	DO229026	LICA	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	0.1111
p.P1769L	DO45299	LIRI	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	0.7582
p.C1763Y	DO36633	READ	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	0.25
p.P1765S	DO234097	THCA	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	0.3056
p.A1780T	DO41211	UCEC	ICGC	PTCTPNSE	DEG_SCF_FBW7_2	0.1389
p.P1770H	SIDM00719	Small Cell Lung Carcinoma	GDSC	PTCTPNSE	DEG_SCF_FBW7_2	0.7694
p.P1770H	ACH-001364	Lung Cancer	CCLE	PTCTPNSE	DEG_SCF_FBW7_2	0.7694
p.P1770H	NCI-H345	lung	COSMIC	PTCTPNSE	DEG_SCF_FBW7_2	0.7694
p.P1757L	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	PTCTPNSE	DEG_SCF_FBW7_2	0.0833
p.P1757L	ACH-000894	Lung Cancer	CCLE	PTCTPNSE	DEG_SCF_FBW7_2	0.0833
p.P1757L	NCI-H1869	lung	COSMIC	PTCTPNSE	DEG_SCF_FBW7_2	0.0833
p.E1779D	ACH-000954	Endometrial/Uterine Cancer	CCLE	PTCTPNSE	DEG_SCF_FBW7_2	0.1667
p.P1765H	NCI-H345	lung	COSMIC	PTCTPNSE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2C7	Protein unc-80 homolog	DEG_SCF_FBW7_2	1766:1773	PTCTPNSE	FBXW7	0.9544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons