DegronMD

Uniprot ID: Q8N2C7

Source protein: Protein unc-80 homolog

Source gene: UNC80

Class: DEG_SPOP_SBC_1

Location: 2924:2928

E3 ligase: SPOP

DEGRON score: 0.9987

ASA_SCORE: 81.14

COIL: 0.9216

CONS_SCORE: 0.3262

DSS_SCORE: 0.3369

HELIX: 0.0314

FCONS_SCORE: 1.0397

RIG_SCORE: 0.7362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2920V	DO234293	ESAD	ICGC	VGTST	DEG_SPOP_SBC_1	0.2222
p.V2919M	DO233168	GACA	ICGC	VGTST	DEG_SPOP_SBC_1	0.1944
p.V2919M	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VGTST	DEG_SPOP_SBC_1	0.1944
p.R2927L	DO50793	LIRI	ICGC	VGTST	DEG_SPOP_SBC_1	0.8428
p.V2924M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VGTST	DEG_SPOP_SBC_1	0.7208
p.V2924M	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VGTST	DEG_SPOP_SBC_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2497:2501	VGTST	SPOP	0.6282	More...
Q14315	Filamin-C	DEG_SPOP_SBC_1	1959:1963	VGTST	SPOP	0.9482	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	2924:2928	VGTST	SPOP	0.9987	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	555:559	VGTST	SPOP	0.7196	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons