DegronMD - Q14315(FLNC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1960C	TCGA-17-Z055	LUAD	TCGA	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation altering degron motif	0.6489
p.S1962Y	TCGA-46-3765	LUSC	TCGA	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation altering degron motif	0.712
p.E1971K	TCGA-EK-A2RK	CESC	TCGA	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.1111
p.E1971K	DO49952	CESC	ICGC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.1111
p.S1952L	DO49939	CESC	ICGC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.1389
p.S1952L	DO234233	ESAD	ICGC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.1389
p.S1952L	DO26605	LUSC	ICGC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.1389
p.R1966Q	DO8336	COAD	ICGC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.25
p.R1966Q	DO219535	LIHC	ICGC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.25
p.R1966Q	DO40804	UCEC	ICGC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.25
p.D1964N	SIDM00545	Melanoma	GDSC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.3056
p.D1964N	ACH-000987	Skin Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.3056
p.D1964N	Mewo	skin	COSMIC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.3056
p.D1973E	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.0556
p.D1973E	ACH-000929	Lung Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.0556
p.D1973E	NCI-H2110	lung	COSMIC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.0556
p.I1969V	ACH-001407	Bladder Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation rewiring degron network	0.1667
p.R1962C	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	VGTST	DEG_SPOP_SBC_1	1959:1963	Mutation altering degron motif	0.8301

Kaplan plot for FLNC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FLNC

UniProt ID: Q14315

Entrez ID: 2318

Protein name: Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FLNC in