DegronMD

Uniprot ID: Q14315

Source protein: Filamin-C

Source gene: FLNC

Class: DEG_SPOP_SBC_1

Location: 1959:1963

E3 ligase: SPOP

DEGRON score: 0.9482

ASA_SCORE: 57.64

COIL: 0.6894

CONS_SCORE: 0.5012

DSS_SCORE: 0.4207

HELIX: 0.0084

FCONS_SCORE: 1.1494

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1960C	TCGA-17-Z055	LUAD	TCGA	VGTST	DEG_SPOP_SBC_1	0.6489
p.S1962Y	TCGA-46-3765	LUSC	TCGA	VGTST	DEG_SPOP_SBC_1	0.712
p.E1971K	TCGA-EK-A2RK	CESC	TCGA	VGTST	DEG_SPOP_SBC_1	0.1111
p.E1971K	DO49952	CESC	ICGC	VGTST	DEG_SPOP_SBC_1	0.1111
p.S1952L	DO49939	CESC	ICGC	VGTST	DEG_SPOP_SBC_1	0.1389
p.S1952L	DO234233	ESAD	ICGC	VGTST	DEG_SPOP_SBC_1	0.1389
p.S1952L	DO26605	LUSC	ICGC	VGTST	DEG_SPOP_SBC_1	0.1389
p.R1966Q	DO8336	COAD	ICGC	VGTST	DEG_SPOP_SBC_1	0.25
p.R1966Q	DO219535	LIHC	ICGC	VGTST	DEG_SPOP_SBC_1	0.25
p.R1966Q	DO40804	UCEC	ICGC	VGTST	DEG_SPOP_SBC_1	0.25
p.D1964N	SIDM00545	Melanoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.3056
p.D1964N	ACH-000987	Skin Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	0.3056
p.D1964N	Mewo	skin	COSMIC	VGTST	DEG_SPOP_SBC_1	0.3056
p.D1973E	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.0556
p.D1973E	ACH-000929	Lung Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	0.0556
p.D1973E	NCI-H2110	lung	COSMIC	VGTST	DEG_SPOP_SBC_1	0.0556
p.I1969V	ACH-001407	Bladder Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	0.1667
p.R1962C	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VGTST	DEG_SPOP_SBC_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2497:2501	VGTST	SPOP	0.6282	More...
Q14315	Filamin-C	DEG_SPOP_SBC_1	1959:1963	VGTST	SPOP	0.9482	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	2924:2928	VGTST	SPOP	0.9987	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	555:559	VGTST	SPOP	0.7196	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons