DegronMD

Uniprot ID: Q9HBB8

Source protein: Cadherin-related family member 5

Source gene: CDHR5

Class: DEG_SPOP_SBC_1

Location: 555:559

E3 ligase: SPOP

DEGRON score: 0.7196

ASA_SCORE: 66.86

COIL: 0.634

CONS_SCORE: 0.4651

DSS_SCORE: 0.8841

HELIX: 0.0214

FCONS_SCORE: 0.8263

RIG_SCORE: 0.4958

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P550L	TCGA-B5-A3FA	UCEC	TCGA	VGTST	DEG_SPOP_SBC_1	0.1944
p.P550L	DO52402	UCEC	ICGC	VGTST	DEG_SPOP_SBC_1	0.1944
p.G556E	TCGA-FS-A1ZZ	SKCM	TCGA	VGTST	DEG_SPOP_SBC_1	0.6087
p.G556E	DO37412	SKCM	ICGC	VGTST	DEG_SPOP_SBC_1	0.6087
p.P550R	TCGA-KU-A66S	HNSC	TCGA	VGTST	DEG_SPOP_SBC_1	0.1944
p.P550R	DO44456	HNSC	ICGC	VGTST	DEG_SPOP_SBC_1	0.1944
p.Q562H	DO48381	BLCA	ICGC	VGTST	DEG_SPOP_SBC_1	0.25
p.S548A	DO230309	COCA	ICGC	VGTST	DEG_SPOP_SBC_1	0.1389
p.P552L	DO229346	LAML	ICGC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	DO230556	LUSC	ICGC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM01040	Ovarian Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM01005	Acute Myeloid Leukemia	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00235	Kidney Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00383	Gastric Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00292	Small Cell Lung Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00252	Biliary Tract Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM01653	Non-Cancerous	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00574	Glioblastoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00207	Glioblastoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00988	Kidney Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00986	Head and Neck Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00380	Acute Myeloid Leukemia	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM01033	Bladder Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00168	Head and Neck Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM01660	Kidney Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM01451	Pancreatic Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.P552L	SIDM00497	Colorectal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.25
p.E552V	DO231610	LINC	ICGC	VGTST	DEG_SPOP_SBC_1	0.25
p.G554S	DO230545	LUSC	ICGC	VGTST	DEG_SPOP_SBC_1	0.3056
p.S567G	DO230545	LUSC	ICGC	VGTST	DEG_SPOP_SBC_1	0.1111
p.P548L	DO38404	STAD	ICGC	VGTST	DEG_SPOP_SBC_1	0.1389
p.S548P	DO229253	THCA	ICGC	VGTST	DEG_SPOP_SBC_1	0.1389
p.A551T	DO229253	THCA	ICGC	VGTST	DEG_SPOP_SBC_1	0.2222
p.P555H	DO229257	THCA	ICGC	VGTST	DEG_SPOP_SBC_1	0.7694
p.P553L	SIDM00477	Esophageal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.2778
p.P553L	ACH-000383	Esophageal Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	0.2778
p.P553L	OE33	oesophagus	COSMIC	VGTST	DEG_SPOP_SBC_1	0.2778
p.G546E	SIDM00856	Other Solid Cancers	GDSC	VGTST	DEG_SPOP_SBC_1	0.0833
p.G546E	ACH-000096	Rhabdoid	CCLE	VGTST	DEG_SPOP_SBC_1	0.0833
p.G546E	G-401	soft_tissue	COSMIC	VGTST	DEG_SPOP_SBC_1	0.0833
p.T565I	SIDM00282	Colorectal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.1667
p.T565I	ACH-000998	Colon/Colorectal Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	0.1667
p.T565I	CW-2	large_intestine	COSMIC	VGTST	DEG_SPOP_SBC_1	0.1667
p.T557S	SIDM00357	Small Cell Lung Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.6005
p.T557S	ACH-002193	Lung Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	0.6005
p.T557S	RERF-LC-FM	lung	COSMIC	VGTST	DEG_SPOP_SBC_1	0.6005
p.G569D	ACH-000431	Lung Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2497:2501	VGTST	SPOP	0.6282	More...
Q14315	Filamin-C	DEG_SPOP_SBC_1	1959:1963	VGTST	SPOP	0.9482	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	2924:2928	VGTST	SPOP	0.9987	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	555:559	VGTST	SPOP	0.7196	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGTST

Degron related mutations and impact score

Drug responses associated with CDHR5 mutations

All proteins holding degron of VGTST