DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 2497:2501

E3 ligase: SPOP

DEGRON score: 0.6282

ASA_SCORE: 83.88

COIL: 0.8904

CONS_SCORE: 0.6409

DSS_SCORE: 0.512

HELIX: 0.0146

FCONS_SCORE: 0.9967

RIG_SCORE: 0.6485

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2510S	SIDM00660	Colorectal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.0833
p.P2510S	SIDM00516	Melanoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.0833
p.P2510S	SIDM00808	Burkitt's Lymphoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.0833
p.P2510S	SIDM01173	Rhabdomyosarcoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.0833
p.P2510S	SIDM01254	Burkitt's Lymphoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.0833
p.T2505A	SIDM00534	Colorectal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.2222
p.T2487R	SIDM01434	Hepatocellular Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2497:2501	VGTST	SPOP	0.6282	More...
Q14315	Filamin-C	DEG_SPOP_SBC_1	1959:1963	VGTST	SPOP	0.9482	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	2924:2928	VGTST	SPOP	0.9987	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	555:559	VGTST	SPOP	0.7196	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons