DegronMD

Uniprot ID: Q8N2C7

Source protein: Protein unc-80 homolog

Source gene: UNC80

Class: LIG_APCC_ABBA_1

Location: 2012:2017

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6526

ASA_SCORE: 80.1

COIL: 0.8967

CONS_SCORE: 0.6258

DSS_SCORE: 0.269

HELIX: 0.0553

FCONS_SCORE: 1.2035

RIG_SCORE: 0.8125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2009L	TCGA-AD-6889	COAD	TCGA	LPVHED	LIG_APCC_ABBA_1	0.25
p.G2002E	TCGA-DX-AB2E	SARC	TCGA	LPVHED	LIG_APCC_ABBA_1	0.0556
p.P2004L	DO8463	COAD	ICGC	LPVHED	LIG_APCC_ABBA_1	0.1111
p.T2013N	DO228580	GACA	ICGC	LPVHED	LIG_APCC_ABBA_1	0.7055
p.E2024D	DO228952	LICA	ICGC	LPVHED	LIG_APCC_ABBA_1	0.1389
p.T2013S	ACH-001031	Rhabdoid	CCLE	LPVHED	LIG_APCC_ABBA_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2C7	Protein unc-80 homolog	LIG_APCC_ABBA_1	2012:2017	LPVHED	APC,CDC20,FZR1	0.6526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons