DegronMD

Uniprot ID: Q8N2C7

Source protein: Protein unc-80 homolog

Source gene: UNC80

Class: DEG_APCC_DBOX_1

Location: 1090:1098

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5763

ASA_SCORE: 79.3

COIL: 0.8017

CONS_SCORE: 0.2957

DSS_SCORE: 0.1625

HELIX: 0.0963

FCONS_SCORE: 0.9997

RIG_SCORE: 0.7418

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1106Y	TCGA-CI-6624	READ	TCGA	KRSSLSGLA	DEG_APCC_DBOX_1	0.1111
p.R1107Q	DO50505	BOCA	ICGC	KRSSLSGLA	DEG_APCC_DBOX_1	0.0833
p.S1103I	DO234277	ESAD	ICGC	KRSSLSGLA	DEG_APCC_DBOX_1	0.1944
p.D1101Y	DO37130	READ	ICGC	KRSSLSGLA	DEG_APCC_DBOX_1	0.25
p.A1098E	SIDM02012	Colorectal Carcinoma	GDSC	KRSSLSGLA	DEG_APCC_DBOX_1	0.659
p.S1108C	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	KRSSLSGLA	DEG_APCC_DBOX_1	0.0556
p.S1108C	ACH-000860	Lung Cancer	CCLE	KRSSLSGLA	DEG_APCC_DBOX_1	0.0556
p.S1108C	NCI-H358	lung	COSMIC	KRSSLSGLA	DEG_APCC_DBOX_1	0.0556
p.I1083T	SIDM00316	Glioblastoma	GDSC	KRSSLSGLA	DEG_APCC_DBOX_1	0.1389
p.I1083T	ACH-000469	Brain Cancer	CCLE	KRSSLSGLA	DEG_APCC_DBOX_1	0.1389
p.I1083T	YH-13	central_nervous_system	COSMIC	KRSSLSGLA	DEG_APCC_DBOX_1	0.1389
p.S1103C	NCI-H358	lung	COSMIC	KRSSLSGLA	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2C7	Protein unc-80 homolog	DEG_APCC_DBOX_1	1090:1098	KRSSLSGLA	APC,CDC20,FZR1	0.5763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons