DegronMD

Uniprot ID: Q8N2C7

Source protein: Protein unc-80 homolog

Source gene: UNC80

Class: DEG_APCC_DBOX_1

Location: 2931:2939

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9047

ASA_SCORE: 97.5667

COIL: 0.7563

CONS_SCORE: 0.3192

DSS_SCORE: 0.4452

HELIX: 0.205

FCONS_SCORE: 0.9601

RIG_SCORE: 0.777

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M2933R	DO50357	ESAD	ICGC	YRLSLATMS	DEG_APCC_DBOX_1	0.8632
p.R2935S	DO52318	LIHC	ICGC	YRLSLATMS	DEG_APCC_DBOX_1	0.7427
p.T2938M	DO233207	GACA	ICGC	YRLSLATMS	DEG_APCC_DBOX_1	0.7423
p.A2931T	ACH-000455	Brain Cancer	CCLE	YRLSLATMS	DEG_APCC_DBOX_1	0.7139
p.A2931V	DO42280	UCEC	ICGC	YRLSLATMS	DEG_APCC_DBOX_1	0.6936
p.A2936V	TCGA-AX-A1CE	UCEC	TCGA	YRLSLATMS	DEG_APCC_DBOX_1	0.5825
p.R2940S	TCGA-UB-A7MB	LIHC	TCGA	YRLSLATMS	DEG_APCC_DBOX_1	0.3056
p.T2940M	NCI-H1755	lung	COSMIC	YRLSLATMS	DEG_APCC_DBOX_1	0.3056
p.T2945M	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	YRLSLATMS	DEG_APCC_DBOX_1	0.1667
p.T2945M	ACH-000282	Lung Cancer	CCLE	YRLSLATMS	DEG_APCC_DBOX_1	0.1667
p.T2945M	NCI-H1755	lung	COSMIC	YRLSLATMS	DEG_APCC_DBOX_1	0.1667

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2C7	Protein unc-80 homolog	DEG_APCC_DBOX_1	2931:2939	YRLSLATMS	APC,CDC20,FZR1	0.9047	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons