DegronMD - Q8TD26(CHD6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G88R	TCGA-49-4487	LUAD	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.6457
p.G88R	DO24780	LUAD	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.6457
p.K387E	TCGA-AC-A23H	BRCA	TCGA	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.3056
p.K387E	DO2401	BRCA	ICGC	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.3056
p.P2592L	TCGA-BF-AAP7	SKCM	TCGA	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.1111
p.P2592L	DO219472	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.1111
p.P2592S	TCGA-BF-AAP7	SKCM	TCGA	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.1111
p.P2592S	DO219472	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.1111
p.G392V	TCGA-CG-5726	STAD	TCGA	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation altering degron motif	0.7532
p.G392V	DO38483	STAD	ICGC	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation altering degron motif	0.7532
p.S2115F	TCGA-CV-A6JM	HNSC	TCGA	LPTPVLT	DEG_SCF_FBW7_1	2125:2131	Mutation rewiring degron network	0.0556
p.S2115F	DO49991	HNSC	ICGC	LPTPVLT	DEG_SCF_FBW7_1	2125:2131	Mutation rewiring degron network	0.0556
p.H385N	TCGA-DA-A1I1	SKCM	TCGA	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.25
p.H385N	DO37966	SKCM	ICGC	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.25
p.P2590R	TCGA-DX-A6BA	SARC	TCGA	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.0556
p.P2590R	DO219995	SARC	ICGC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.0556
p.G81E	TCGA-DX-AB2E	SARC	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation rewiring degron network	0.25
p.G81E	DO220073	SARC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation rewiring degron network	0.25
p.K99T	TCGA-EC-A1QX	UCEC	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation substituting flanking lysine	0.1944
p.K99T	DO42592	UCEC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation substituting flanking lysine	0.1944
p.P2143S	TCGA-EE-A20C	SKCM	TCGA	VLTSS	DEG_SPOP_SBC_1	2129:2133	Mutation rewiring degron network	0.0556
p.P2143S	DO222775	MELA	ICGC	VLTSS	DEG_SPOP_SBC_1	2129:2133	Mutation rewiring degron network	0.0556
p.P2143S	DO47665	SKCM	ICGC	VLTSS	DEG_SPOP_SBC_1	2129:2133	Mutation rewiring degron network	0.0556
p.S2594F	TCGA-EE-A3AE	SKCM	TCGA	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.1667
p.S2594F	DO37802	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.1667
p.L2613R	TCGA-EE-A3J4	SKCM	TCGA	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.0833
p.L2613R	DO48604	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.0833
p.G88E	TCGA-MA-AA3Z	CESC	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.6087
p.G88E	DO219722	CESC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.6087
p.E83A	DO222737	COCA	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation rewiring degron network	0.3056
p.H79R	DO50453	ESAD	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation rewiring degron network	0.1944
p.T90I	DO234234	ESAD	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.7078
p.R379H	DO223093	ESCA	ICGC	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.0833
p.P2599L	DO11854	GBM	ICGC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.3056
p.T2603N	DO228952	LICA	ICGC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation altering degron motif	0.7055
p.R2137Q	DO228998	LICA	ICGC	LPTPVLT	DEG_SCF_FBW7_1	2125:2131	Mutation rewiring degron network	0.1667
p.R2137Q	DO228998	LICA	ICGC	VLTSS	DEG_SPOP_SBC_1	2129:2133	Mutation rewiring degron network	0.2222
p.A389E	DO229029	LICA	ICGC	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation altering degron motif	0.659
p.Q2118K	DO229035	LICA	ICGC	LPTPVLT	DEG_SCF_FBW7_1	2125:2131	Mutation rewiring degron network	0.1389
p.K99E	DO45299	LIRI	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation substituting flanking lysine	0.1944
p.R379C	DO220886	MELA	ICGC	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.0833
p.S2604I	SIDM00282	Colorectal Carcinoma	GDSC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation altering degron motif	0.7341
p.T386A	SIDM00282	Colorectal Carcinoma	GDSC	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.2778
p.T386A	ACH-000998	Colon/Colorectal Cancer	CCLE	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.2778
p.T386A	CW-2	large intestine	COSMIC	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.2778
p.T90A	SIDM00847	Rhabdomyosarcoma	GDSC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.7139
p.T90A	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.7139
p.T90A	ACH-000169	Sarcoma	CCLE	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.7139
p.T90A	ACH-002253	Lymphoma	CCLE	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.7139
p.T90A	JSC-1	haematopoietic and lymphoid tissue	COSMIC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.7139
p.T90A	RD	soft tissue	COSMIC	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation altering degron motif	0.7139
p.P2599R	SIDM00225	Melanoma	GDSC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.3056
p.P2599R	ACH-002143	Skin Cancer	CCLE	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.3056
p.P2599R	IST-MEL1	skin	COSMIC	AITTS	DEG_SPOP_SBC_1	2600:2604	Mutation rewiring degron network	0.3056
p.K97R	ACH-000128	Brain Cancer	CCLE	DSGGGGT	DEG_SCF_TRCP1_1	84:90	Mutation substituting flanking lysine	0.25
p.P2128L	ACH-001556	Lung Cancer	CCLE	LPTPVLT	DEG_SCF_FBW7_1	2125:2131	Mutation altering degron motif	0.7582
p.E398Q	SCC-9	upper aerodigestive tract	COSMIC	DAETGE	DEG_Kelch_Keap1_1	388:393	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD6

UniProt ID: Q8TD26

Entrez ID: 84181

Protein name: Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHD6 in