DegronMD

Uniprot ID: Q8TD26

Source protein: Chromodomain-helicase-DNA-binding protein 6

Source gene: CHD6

Class: DEG_SCF_FBW7_1

Location: 2125:2131

E3 ligase: FBXW7

DEGRON score: 0.9934

ASA_SCORE: 67.2429

COIL: 0.8609

CONS_SCORE: 0.3375

DSS_SCORE: 0.5636

HELIX: 0.0257

FCONS_SCORE: 0.9762

RIG_SCORE: 0.7038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2115F	TCGA-CV-A6JM	HNSC	TCGA	LPTPVLT	DEG_SCF_FBW7_1	0.0556
p.S2115F	DO49991	HNSC	ICGC	LPTPVLT	DEG_SCF_FBW7_1	0.0556
p.R2137Q	DO228998	LICA	ICGC	LPTPVLT	DEG_SCF_FBW7_1	0.1667
p.Q2118K	DO229035	LICA	ICGC	LPTPVLT	DEG_SCF_FBW7_1	0.1389
p.P2128L	ACH-001556	Lung Cancer	CCLE	LPTPVLT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SCF_FBW7_1	2125:2131	LPTPVLT	FBXW7	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons