DegronMD

Uniprot ID: Q8TD26

Source protein: Chromodomain-helicase-DNA-binding protein 6

Source gene: CHD6

Class: DEG_Kelch_Keap1_1

Location: 388:393

E3 ligase: KEAP1

DEGRON score: 0.5893

ASA_SCORE: 80.8167

COIL: 0.757

CONS_SCORE: 0.3832

DSS_SCORE: 0.2995

HELIX: 0.0828

FCONS_SCORE: 0.7709

RIG_SCORE: 0.7313

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K387E	TCGA-AC-A23H	BRCA	TCGA	DAETGE	DEG_Kelch_Keap1_1	0.3056
p.K387E	DO2401	BRCA	ICGC	DAETGE	DEG_Kelch_Keap1_1	0.3056
p.G392V	TCGA-CG-5726	STAD	TCGA	DAETGE	DEG_Kelch_Keap1_1	0.7532
p.G392V	DO38483	STAD	ICGC	DAETGE	DEG_Kelch_Keap1_1	0.7532
p.H385N	TCGA-DA-A1I1	SKCM	TCGA	DAETGE	DEG_Kelch_Keap1_1	0.25
p.H385N	DO37966	SKCM	ICGC	DAETGE	DEG_Kelch_Keap1_1	0.25
p.R379H	DO223093	ESCA	ICGC	DAETGE	DEG_Kelch_Keap1_1	0.0833
p.A389E	DO229029	LICA	ICGC	DAETGE	DEG_Kelch_Keap1_1	0.659
p.R379C	DO220886	MELA	ICGC	DAETGE	DEG_Kelch_Keap1_1	0.0833
p.T386A	SIDM00282	Colorectal Carcinoma	GDSC	DAETGE	DEG_Kelch_Keap1_1	0.2778
p.T386A	ACH-000998	Colon/Colorectal Cancer	CCLE	DAETGE	DEG_Kelch_Keap1_1	0.2778
p.T386A	CW-2	large_intestine	COSMIC	DAETGE	DEG_Kelch_Keap1_1	0.2778
p.E398Q	SCC-9	upper_aerodigestive_tract	COSMIC	DAETGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_Kelch_Keap1_1	388:393	DAETGE	KEAP1	0.5893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons