DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DAETGE
Uniprot ID:
Q8TD26
Source protein:
Chromodomain-helicase-DNA-binding protein 6
Source gene:
CHD6
Class:
DEG_Kelch_Keap1_1
Location:
388:393
E3 ligase:
KEAP1
DEGRON score:
0.5893
ASA_SCORE:
80.8167
COIL:
0.757
CONS_SCORE:
0.3832
DSS_SCORE:
0.2995
HELIX:
0.0828
FCONS_SCORE:
0.7709
RIG_SCORE:
0.7313
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G392V
TCGA-CG-5726
STAD
TCGA
DAETGE
DEG_Kelch_Keap1_1
0.7532
p.G392V
DO38483
STAD
ICGC
DAETGE
DEG_Kelch_Keap1_1
0.7532
p.A389E
DO229029
LICA
ICGC
DAETGE
DEG_Kelch_Keap1_1
0.659
p.K387E
TCGA-AC-A23H
BRCA
TCGA
DAETGE
DEG_Kelch_Keap1_1
0.3056
p.K387E
DO2401
BRCA
ICGC
DAETGE
DEG_Kelch_Keap1_1
0.3056
p.T386A
SIDM00282
Colorectal Carcinoma
GDSC
DAETGE
DEG_Kelch_Keap1_1
0.2778
p.T386A
ACH-000998
Colon/Colorectal Cancer
CCLE
DAETGE
DEG_Kelch_Keap1_1
0.2778
p.T386A
CW-2
large_intestine
COSMIC
DAETGE
DEG_Kelch_Keap1_1
0.2778
p.H385N
TCGA-DA-A1I1
SKCM
TCGA
DAETGE
DEG_Kelch_Keap1_1
0.25
p.H385N
DO37966
SKCM
ICGC
DAETGE
DEG_Kelch_Keap1_1
0.25
p.E398Q
SCC-9
upper_aerodigestive_tract
COSMIC
DAETGE
DEG_Kelch_Keap1_1
0.1944
p.R379H
DO223093
ESCA
ICGC
DAETGE
DEG_Kelch_Keap1_1
0.0833
p.R379C
DO220886
MELA
ICGC
DAETGE
DEG_Kelch_Keap1_1
0.0833
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Drug responses associated with CHD6 mutations
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Cancer
Mutation (In Degron?)
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All proteins holding degron of DAETGE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TD26
Chromodomain-helicase-DNA-binding protein 6
DEG_Kelch_Keap1_1
388:393
DAETGE
KEAP1
0.5893
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