DegronMD

Uniprot ID: Q8TD26

Source protein: Chromodomain-helicase-DNA-binding protein 6

Source gene: CHD6

Class: DEG_SCF_TRCP1_1

Location: 84:90

E3 ligase: BTRC

DEGRON score: 0.9991

ASA_SCORE: 70.1857

COIL: 0.9589

CONS_SCORE: 0.4258

DSS_SCORE: 0.715

HELIX: 0.0151

FCONS_SCORE: 1.1278

RIG_SCORE: 0.5092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G88R	TCGA-49-4487	LUAD	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	0.6457
p.G88R	DO24780	LUAD	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.6457
p.G81E	TCGA-DX-AB2E	SARC	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	0.25
p.G81E	DO220073	SARC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.25
p.K99T	TCGA-EC-A1QX	UCEC	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	0.1944
p.K99T	DO42592	UCEC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.1944
p.G88E	TCGA-MA-AA3Z	CESC	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	0.6087
p.G88E	DO219722	CESC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.6087
p.E83A	DO222737	COCA	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.3056
p.H79R	DO50453	ESAD	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.1944
p.T90I	DO234234	ESAD	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.7078
p.K99E	DO45299	LIRI	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.1944
p.T90A	SIDM00847	Rhabdomyosarcoma	GDSC	DSGGGGT	DEG_SCF_TRCP1_1	0.7139
p.T90A	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGGGT	DEG_SCF_TRCP1_1	0.7139
p.T90A	ACH-000169	Sarcoma	CCLE	DSGGGGT	DEG_SCF_TRCP1_1	0.7139
p.T90A	ACH-002253	Lymphoma	CCLE	DSGGGGT	DEG_SCF_TRCP1_1	0.7139
p.T90A	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGGGT	DEG_SCF_TRCP1_1	0.7139
p.T90A	RD	soft_tissue	COSMIC	DSGGGGT	DEG_SCF_TRCP1_1	0.7139
p.K97R	ACH-000128	Brain Cancer	CCLE	DSGGGGT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SCF_TRCP1_1	4:10	DSGGGGT	BTRC	0.9634	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SCF_TRCP1_1	84:90	DSGGGGT	BTRC	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons