DegronMD

Uniprot ID: Q8IWZ3

Source protein: Ankyrin repeat and KH domain-containing protein 1

Source gene: ANKHD1

Class: DEG_SCF_TRCP1_1

Location: 4:10

E3 ligase: BTRC

DEGRON score: 0.9634

ASA_SCORE: 58.7

COIL: 0.8237

CONS_SCORE: 0.3514

DSS_SCORE: 0.8489

HELIX: 0.0439

FCONS_SCORE: 0.8648

RIG_SCORE: 0.5522

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V19G	TCGA-AA-3947	COAD	TCGA	DSGGGGT	DEG_SCF_TRCP1_1	0.0833
p.V19G	DO8192	COAD	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.0833
p.H14D	DO516	BLCA	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.2222
p.S6C	DO516	BLCA	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.8652
p.S5G	DO45061	LINC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.8104
p.S5N	DO45061	LINC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.818
p.Y8N	DO220239	SARC	ICGC	DSGGGGT	DEG_SCF_TRCP1_1	0.817

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SCF_TRCP1_1	4:10	DSGGGGT	BTRC	0.9634	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SCF_TRCP1_1	84:90	DSGGGGT	BTRC	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons