DegronMD - Q9Y5T5(USP16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V195M	TCGA-12-5301	GBM	TCGA	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.0556
p.E173D	TCGA-AP-A059	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.1111
p.E786Q	TCGA-CV-A45P	HNSC	TCGA	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.1667
p.P185H	TCGA-D1-A17U	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation altering degron motif	0.6583
p.P553L	TCGA-D3-A3C7	SKCM	TCGA	VLTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.M187V	TCGA-D7-A6EY	STAD	TCGA	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.2778
p.N558S	TCGA-D7-A6EY	STAD	TCGA	VLTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.L775F	TCGA-EO-A22U	UCEC	TCGA	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation altering degron motif	0.587
p.E786K	TCGA-FD-A5BT	BLCA	TCGA	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.1667
p.E178K	TCGA-FS-A1ZQ	SKCM	TCGA	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.25
p.P185S	TCGA-GF-A6C9	SKCM	TCGA	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation altering degron motif	0.5641
p.A768T	TCGA-VQ-A8P2	STAD	TCGA	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.1389
p.E785K	DO44032	BLCA	ICGC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.1944
p.G194E	DO234395	ESAD	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.0833
p.E174K	DO233619	GACA	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.1389
p.V194M	DO11746	GBM	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.0833
p.E785Q	DO219026	HNSC	ICGC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.1944
p.G778V	DO229025	LICA	ICGC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation altering degron motif	0.7532
p.V194L	DO229034	LICA	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.0833
p.M786I	DO229038	LICA	ICGC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.1667
p.T766I	DO231810	LINC	ICGC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.0833
p.E787D	DO232761	PBCA	ICGC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.1389
p.Q191E	DO51103	PRAD	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.1667
p.E177K	DO37442	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation substituting flanking lysine	0.3333
p.P182L	DO47569	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation altering degron motif	0.7582
p.P184S	DO51254	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation altering degron motif	0.6752
p.M186V	DO50118	STAD	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.3056
p.N187S	DO50118	STAD	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.2778
p.A767T	DO51761	STAD	ICGC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.1111
p.P184H	DO41887	UCEC	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation altering degron motif	0.7694
p.L774F	DO43755	UCEC	ICGC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.3056
p.E172D	DO41361	UCEC	ICGC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.0833
p.G779S	SIDM01943	Colorectal Carcinoma	GDSC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation altering degron motif	0.5882
p.F785C	SIDM00845	Burkitt's Lymphoma	GDSC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation rewiring degron network	0.1944
p.E175D	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.1667
p.E175D	ACH-000444	Lung Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.1667
p.E175D	LU-99A	lung	COSMIC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.1667
p.E173K	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.1111
p.E173K	ACH-000726	Esophageal Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.1111
p.T550S	ACH-001853	Bile Duct Cancer	CCLE	VLTSS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7116
p.G790V	KYSE-70	oesophagus	COSMIC	LVLHGD	LIG_APCC_ABBA_1	775:780	Mutation substituting flanking lysine	0.1667
p.E174D	LU-99A	lung	COSMIC	AKENP	DEG_APCC_KENBOX_2	181:185	Mutation rewiring degron network	0.1389

Kaplan plot for USP16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP16

UniProt ID: Q9Y5T5

Entrez ID: 10600

Protein name: Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP16 in