DegronMD

Uniprot ID: Q9Y5T5

Source protein: Ubiquitin carboxyl-terminal hydrolase 16

Source gene: USP16

Class: LIG_APCC_ABBA_1

Location: 775:780

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5025

ASA_SCORE: 76.6

COIL: 0.678

CONS_SCORE: 0.2566

DSS_SCORE: 0.3367

HELIX: 0.178

FCONS_SCORE: 1.0117

RIG_SCORE: 0.7854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E786Q	TCGA-CV-A45P	HNSC	TCGA	LVLHGD	LIG_APCC_ABBA_1	0.1667
p.L775F	TCGA-EO-A22U	UCEC	TCGA	LVLHGD	LIG_APCC_ABBA_1	0.587
p.E786K	TCGA-FD-A5BT	BLCA	TCGA	LVLHGD	LIG_APCC_ABBA_1	0.1667
p.A768T	TCGA-VQ-A8P2	STAD	TCGA	LVLHGD	LIG_APCC_ABBA_1	0.1389
p.E785K	DO44032	BLCA	ICGC	LVLHGD	LIG_APCC_ABBA_1	0.1944
p.E785Q	DO219026	HNSC	ICGC	LVLHGD	LIG_APCC_ABBA_1	0.1944
p.G778V	DO229025	LICA	ICGC	LVLHGD	LIG_APCC_ABBA_1	0.7532
p.M786I	DO229038	LICA	ICGC	LVLHGD	LIG_APCC_ABBA_1	0.1667
p.T766I	DO231810	LINC	ICGC	LVLHGD	LIG_APCC_ABBA_1	0.0833
p.E787D	DO232761	PBCA	ICGC	LVLHGD	LIG_APCC_ABBA_1	0.1389
p.A767T	DO51761	STAD	ICGC	LVLHGD	LIG_APCC_ABBA_1	0.1111
p.L774F	DO43755	UCEC	ICGC	LVLHGD	LIG_APCC_ABBA_1	0.3056
p.G779S	SIDM01943	Colorectal Carcinoma	GDSC	LVLHGD	LIG_APCC_ABBA_1	0.5882
p.F785C	SIDM00845	Burkitt's Lymphoma	GDSC	LVLHGD	LIG_APCC_ABBA_1	0.1944
p.G790V	KYSE-70	oesophagus	COSMIC	LVLHGD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	LIG_APCC_ABBA_1	775:780	LVLHGD	APC,CDC20,FZR1	0.5025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons