DegronMD

Uniprot ID: Q9Y6Q6

Source protein: Tumor necrosis factor receptor superfamily member 11A

Source gene: TNFRSF11A

Class: DEG_SPOP_SBC_1

Location: 193:197

E3 ligase: SPOP

DEGRON score: 0.5093

ASA_SCORE: 53.6

COIL: 0.7982

CONS_SCORE: 0.7674

DSS_SCORE: 0.4692

HELIX: 0.108

FCONS_SCORE: 1.1881

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D191N	TCGA-A5-A2K5	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.2778
p.D191N	DO41379	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.2778
p.T187A	TCGA-A6-3807	COAD	TCGA	VCSSS	DEG_SPOP_SBC_1	0.1667
p.T187A	DO9034	COAD	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1667
p.E188D	TCGA-EO-A22R	UCEC	TCGA	VCSSS	DEG_SPOP_SBC_1	0.1944
p.E188D	DO42713	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1944
p.E188K	TCGA-FW-A3R5	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	0.1944
p.E188K	DO37406	SKCM	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1944
p.N205H	TCGA-GN-A26C	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	0.1111
p.N205H	DO37782	SKCM	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1111
p.A192V	DO228483	BRCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.A192V	DO229010	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.A192V	DO229013	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.A192V	DO229016	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.A192V	DO229003	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.A192V	DO229005	COCA	ICGC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.A192V	DO229346	LAML	ICGC	VCSSS	DEG_SPOP_SBC_1	0.3056
p.G206V	DO43041	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.0833
p.G206V	DO42793	UCEC	ICGC	VCSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1W1	Rho guanine nucleotide exchange factor 28	DEG_SPOP_SBC_1	577:581	VCSSS	SPOP	0.9989	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	624:628	VCSSS	SPOP	0.9791	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1546:1550	VCSSS	SPOP	0.8548	More...
Q9NWQ4	G patch domain-containing protein 2-like	DEG_SPOP_SBC_1	226:230	VCSSS	SPOP	0.9077	More...
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SPOP_SBC_1	282:286	VCSSS	SPOP	0.9458	More...
Q9Y6Q6	Tumor necrosis factor receptor superfamily member 11A	DEG_SPOP_SBC_1	193:197	VCSSS	SPOP	0.5093	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	315:319	VCSSS	SPOP	0.632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons