DegronMD - Q9ULJ3(ZBTB21)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P277L	TCGA-AA-3855	COAD	TCGA	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.P277L	DO10742	COAD	ICGC	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.R276L	TCGA-D3-A3CE	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.R276L	DO37405	SKCM	ICGC	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.P289H	TCGA-FS-A1ZN	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.25
p.P289H	DO38165	SKCM	ICGC	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.25
p.R276Q	TCGA-HT-A5RA	LGG	TCGA	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.R276Q	DO44589	LGG	ICGC	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.E1023K	TCGA-P3-A5Q5	HNSC	TCGA	PTPATE	DEG_SCF_FBW7_2	1011:1016	Mutation rewiring degron network	0.1389
p.E1016K	TCGA-UY-A9PH	BLCA	TCGA	PTPATE	DEG_SCF_FBW7_2	1011:1016	Mutation altering degron motif	0.7022
p.S467T	DO233634	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation blocking phosphorylation signal	0.5833
p.K469T	DO46378	OV	ICGC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation substituting flanking lysine	0.1944
p.T1012A	SIDM00933	Breast Carcinoma	GDSC	PTPATE	DEG_SCF_FBW7_2	1011:1016	Mutation altering degron motif	0.7139
p.T1012A	SIDM00678	Bladder Carcinoma	GDSC	PTPATE	DEG_SCF_FBW7_2	1011:1016	Mutation altering degron motif	0.7139
p.T1012A	SIDM00203	Ewing's Sarcoma	GDSC	PTPATE	DEG_SCF_FBW7_2	1011:1016	Mutation altering degron motif	0.7139
p.T1012A	SIDM00875	Breast Carcinoma	GDSC	PTPATE	DEG_SCF_FBW7_2	1011:1016	Mutation altering degron motif	0.7139
p.T1012A	SIDM01042	Breast Carcinoma	GDSC	PTPATE	DEG_SCF_FBW7_2	1011:1016	Mutation altering degron motif	0.7139
p.L291V	SIDM00129	Melanoma	GDSC	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.L291V	ACH-002121	Skin Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.L291V	G-MEL	skin	COSMIC	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.L468M	SIDM00002	Neuroblastoma	GDSC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1111
p.L468M	ACH-002340	Neuroblastoma	CCLE	AASSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1111
p.L468M	NBsusSR	autonomic ganglia	COSMIC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1111
p.N296S	SIDM00928	Breast Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.N296S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VCSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.A451V	SIDM00971	Breast Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1944
p.A451V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1944
p.A451V	SIDM00628	Breast Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1944
p.T453A	SIDM00493	Other Solid Cancers	GDSC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation blocking phosphorylation signal	0.6944
p.T453A	SIDM00863	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation blocking phosphorylation signal	0.6944
p.T453A	SIDM00641	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	456:460	Mutation blocking phosphorylation signal	0.6944
p.A1014T	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PTPATE	DEG_SCF_FBW7_2	1011:1016	Mutation altering degron motif	0.6028

Kaplan plot for ZBTB21 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB21

UniProt ID: Q9ULJ3

Entrez ID: 49854

Protein name: Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB21 in