DegronMD

Uniprot ID: Q9ULJ3

Source protein: Zinc finger and BTB domain-containing protein 21

Source gene: ZBTB21

Class: DEG_SCF_FBW7_2

Location: 1011:1016

E3 ligase: FBXW7

DEGRON score: 0.7912

ASA_SCORE: 64.9833

COIL: 0.5308

CONS_SCORE: 0.5026

DSS_SCORE: 0.6755

HELIX: 0.047

FCONS_SCORE: 0.8318

RIG_SCORE: 0.666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1023K	TCGA-P3-A5Q5	HNSC	TCGA	PTPATE	DEG_SCF_FBW7_2	0.1389
p.E1016K	TCGA-UY-A9PH	BLCA	TCGA	PTPATE	DEG_SCF_FBW7_2	0.7022
p.T1012A	SIDM00933	Breast Carcinoma	GDSC	PTPATE	DEG_SCF_FBW7_2	0.7139
p.T1012A	SIDM00678	Bladder Carcinoma	GDSC	PTPATE	DEG_SCF_FBW7_2	0.7139
p.T1012A	SIDM00203	Ewing's Sarcoma	GDSC	PTPATE	DEG_SCF_FBW7_2	0.7139
p.T1012A	SIDM00875	Breast Carcinoma	GDSC	PTPATE	DEG_SCF_FBW7_2	0.7139
p.T1012A	SIDM01042	Breast Carcinoma	GDSC	PTPATE	DEG_SCF_FBW7_2	0.7139
p.A1014T	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PTPATE	DEG_SCF_FBW7_2	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SCF_FBW7_2	1011:1016	PTPATE	FBXW7	0.7912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons