DegronMD

Uniprot ID: Q9ULJ3

Source protein: Zinc finger and BTB domain-containing protein 21

Source gene: ZBTB21

Class: DEG_SPOP_SBC_1

Location: 282:286

E3 ligase: SPOP

DEGRON score: 0.9458

ASA_SCORE: 65.2

COIL: 0.7714

CONS_SCORE: 0.5737

DSS_SCORE: 0.4369

HELIX: 0.0448

FCONS_SCORE: 1.0792

RIG_SCORE: 0.6994

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P277L	TCGA-AA-3855	COAD	TCGA	VCSSS	DEG_SPOP_SBC_1	0.1944
p.P277L	DO10742	COAD	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1944
p.R276L	TCGA-D3-A3CE	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	0.1667
p.R276L	DO37405	SKCM	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1667
p.P289H	TCGA-FS-A1ZN	SKCM	TCGA	VCSSS	DEG_SPOP_SBC_1	0.25
p.P289H	DO38165	SKCM	ICGC	VCSSS	DEG_SPOP_SBC_1	0.25
p.R276Q	TCGA-HT-A5RA	LGG	TCGA	VCSSS	DEG_SPOP_SBC_1	0.1667
p.R276Q	DO44589	LGG	ICGC	VCSSS	DEG_SPOP_SBC_1	0.1667
p.L291V	SIDM00129	Melanoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.1944
p.L291V	ACH-002121	Skin Cancer	CCLE	VCSSS	DEG_SPOP_SBC_1	0.1944
p.L291V	G-MEL	skin	COSMIC	VCSSS	DEG_SPOP_SBC_1	0.1944
p.N296S	SIDM00928	Breast Carcinoma	GDSC	VCSSS	DEG_SPOP_SBC_1	0.0556
p.N296S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VCSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1W1	Rho guanine nucleotide exchange factor 28	DEG_SPOP_SBC_1	577:581	VCSSS	SPOP	0.9989	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	624:628	VCSSS	SPOP	0.9791	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1546:1550	VCSSS	SPOP	0.8548	More...
Q9NWQ4	G patch domain-containing protein 2-like	DEG_SPOP_SBC_1	226:230	VCSSS	SPOP	0.9077	More...
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SPOP_SBC_1	282:286	VCSSS	SPOP	0.9458	More...
Q9Y6Q6	Tumor necrosis factor receptor superfamily member 11A	DEG_SPOP_SBC_1	193:197	VCSSS	SPOP	0.5093	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	315:319	VCSSS	SPOP	0.632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons