DegronMD

Uniprot ID: Q9NWQ4

Source protein: G patch domain-containing protein 2-like

Source gene: GPATCH2L

Class: DEG_SPOP_SBC_1

Location: 176:180

E3 ligase: SPOP

DEGRON score: 0.7902

ASA_SCORE: 75

COIL: 0.7546

CONS_SCORE: 0.5366

DSS_SCORE: 0.4143

HELIX: 0.1164

FCONS_SCORE: 0.9425

RIG_SCORE: 0.675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R170S	TCGA-55-6979	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	0.1667
p.R170S	DO24110	LUAD	ICGC	PWTSS	DEG_SPOP_SBC_1	0.1667
p.Q166H	TCGA-55-7994	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	0.0556
p.Q166H	DO45311	LUAD	ICGC	PWTSS	DEG_SPOP_SBC_1	0.0556
p.R167H	TCGA-AJ-A3EL	UCEC	TCGA	PWTSS	DEG_SPOP_SBC_1	0.0833
p.R167H	DO41542	UCEC	ICGC	PWTSS	DEG_SPOP_SBC_1	0.0833
p.P176S	DO222843	MELA	ICGC	PWTSS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40200	T-cell surface protein tactile	DEG_SPOP_SBC_1	446:450	PWTSS	SPOP	0.6584	More...
Q08211	ATP-dependent RNA helicase A	DEG_SPOP_SBC_1	341:345	PWTSS	SPOP	0.9938	More...
Q9NWQ4	G patch domain-containing protein 2-like	DEG_SPOP_SBC_1	176:180	PWTSS	SPOP	0.7902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons