DegronMD

Uniprot ID: P40200

Source protein: T-cell surface protein tactile

Source gene: CD96

Class: DEG_SPOP_SBC_1

Location: 446:450

E3 ligase: SPOP

DEGRON score: 0.6584

ASA_SCORE: 68.88

COIL: 0.6304

CONS_SCORE: 0.6239

DSS_SCORE: 0.5

HELIX: 0.0228

FCONS_SCORE: 1.0557

RIG_SCORE: 0.6886

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G442V	TCGA-44-2657	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	0.2222
p.S449Y	TCGA-53-A4EZ	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	0.712
p.G442C	TCGA-78-7155	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	0.2222
p.R460Q	TCGA-92-8063	LUSC	TCGA	PWTSS	DEG_SPOP_SBC_1	0.0556
p.T439I	TCGA-A5-A0G2	UCEC	TCGA	PWTSS	DEG_SPOP_SBC_1	0.1389
p.S436T	TCGA-B0-5710	KIRC	TCGA	PWTSS	DEG_SPOP_SBC_1	0.0556
p.G451W	TCGA-D3-A3CE	SKCM	TCGA	PWTSS	DEG_SPOP_SBC_1	0.3056
p.R441Q	TCGA-VS-A959	CESC	TCGA	PWTSS	DEG_SPOP_SBC_1	0.1944
p.E448K	DO44048	BLCA	ICGC	PWTSS	DEG_SPOP_SBC_1	0.7022
p.E448K	DO11429	GBM	ICGC	PWTSS	DEG_SPOP_SBC_1	0.7022
p.S451N	DO225131	BRCA	ICGC	PWTSS	DEG_SPOP_SBC_1	0.3056
p.R444L	DO225357	BRCA	ICGC	PWTSS	DEG_SPOP_SBC_1	0.2778
p.Y450H	DO2341	BRCA	ICGC	PWTSS	DEG_SPOP_SBC_1	0.7229
p.A457S	DO228215	LICA	ICGC	PWTSS	DEG_SPOP_SBC_1	0.1389
p.G458D	DO23168	LINC	ICGC	PWTSS	DEG_SPOP_SBC_1	0.1111
p.P446H	DO45316	LUAD	ICGC	PWTSS	DEG_SPOP_SBC_1	0.7694
p.R444Q	DO26941	LUSC	ICGC	PWTSS	DEG_SPOP_SBC_1	0.2778
p.S452L	DO219771	UCEC	ICGC	PWTSS	DEG_SPOP_SBC_1	0.2778
p.R441L	SIDM00324	Neuroblastoma	GDSC	PWTSS	DEG_SPOP_SBC_1	0.1944
p.R441L	TGW	autonomic_ganglia	COSMIC	PWTSS	DEG_SPOP_SBC_1	0.1944
p.V458F	SIDM01228	Melanoma	GDSC	PWTSS	DEG_SPOP_SBC_1	0.1111
p.V458F	CHL-1	skin	COSMIC	PWTSS	DEG_SPOP_SBC_1	0.1111
p.A457V	ACH-000394	Lung Cancer	CCLE	PWTSS	DEG_SPOP_SBC_1	0.1389
p.A457V	NCI-H2081	lung	COSMIC	PWTSS	DEG_SPOP_SBC_1	0.1389
p.V442F	ACH-001024	Skin Cancer	CCLE	PWTSS	DEG_SPOP_SBC_1	0.2222
p.V442F	CHL-1	skin	COSMIC	PWTSS	DEG_SPOP_SBC_1	0.2222
p.S452P	ACH-001642	Lymphoma	CCLE	PWTSS	DEG_SPOP_SBC_1	0.2778
p.S452P	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PWTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40200	T-cell surface protein tactile	DEG_SPOP_SBC_1	446:450	PWTSS	SPOP	0.6584	More...
Q08211	ATP-dependent RNA helicase A	DEG_SPOP_SBC_1	341:345	PWTSS	SPOP	0.9938	More...
Q9NWQ4	G patch domain-containing protein 2-like	DEG_SPOP_SBC_1	176:180	PWTSS	SPOP	0.7902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PWTSS

Degron related mutations and impact score

Drug responses associated with CD96 mutations

All proteins holding degron of PWTSS