DegronMD - P40200(CD96)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G442V	TCGA-44-2657	LUAD	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1111
p.G442V	TCGA-44-2657	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.S449Y	TCGA-53-A4EZ	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.712
p.A409E	TCGA-58-8386	LUSC	TCGA	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25
p.G442C	TCGA-78-7155	LUAD	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1111
p.G442C	TCGA-78-7155	LUAD	TCGA	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.R460Q	TCGA-92-8063	LUSC	TCGA	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0556
p.T439I	TCGA-A5-A0G2	UCEC	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1944
p.T439I	TCGA-A5-A0G2	UCEC	TCGA	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.S436T	TCGA-B0-5710	KIRC	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.2778
p.S436T	TCGA-B0-5710	KIRC	TCGA	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0556
p.G451W	TCGA-D3-A3CE	SKCM	TCGA	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.L419I	TCGA-GN-A26D	SKCM	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1111
p.L419I	TCGA-GN-A26D	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.25
p.R441Q	TCGA-VS-A959	CESC	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1389
p.R441Q	TCGA-VS-A959	CESC	TCGA	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.E448K	DO44048	BLCA	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7022
p.E448K	DO11429	GBM	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7022
p.P417T	DO220822	BRCA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.0556
p.P417T	DO220822	BRCA	ICGC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.3056
p.S451N	DO225131	BRCA	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.R444L	DO225357	BRCA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.0556
p.R444L	DO225357	BRCA	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.Y450H	DO2341	BRCA	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7229
p.R425Q	DO51640	CESC	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.2778
p.R425Q	DO51640	CESC	ICGC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0833
p.S420T	DO16308	KIRC	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1389
p.S420T	DO16308	KIRC	ICGC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2222
p.A457S	DO228215	LICA	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.G435V	DO229018	LICA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.3056
p.S421I	DO229041	LICA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1667
p.S421I	DO229041	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1944
p.G458D	DO23168	LINC	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.P446H	DO45316	LUAD	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7694
p.S433Y	DO45319	LUAD	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation altering degron motif	0.712
p.G426C	DO23590	LUAD	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.3056
p.G426C	DO23590	LUAD	ICGC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0556
p.G426V	DO25020	LUAD	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.3056
p.G426V	DO25020	LUAD	ICGC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0556
p.R444Q	DO26941	LUSC	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.0556
p.R444Q	DO26941	LUSC	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.S434C	DO46897	RECA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation altering degron motif	0.8652
p.P430S	DO229453	SKCA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation altering degron motif	0.6752
p.G435W	DO37405	SKCM	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.3056
p.L403I	DO37480	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0833
p.S452L	DO219771	UCEC	ICGC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.T423I	DO41235	UCEC	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.2222
p.T423I	DO41235	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1389
p.R441L	SIDM00324	Neuroblastoma	GDSC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1389
p.R441L	SIDM00324	Neuroblastoma	GDSC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.R441L	TGW	autonomic ganglia	COSMIC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1389
p.R441L	TGW	autonomic ganglia	COSMIC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.V458F	SIDM01228	Melanoma	GDSC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.V458F	CHL-1	skin	COSMIC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.V406E	SIDM01490	Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1667
p.A457V	ACH-000394	Lung Cancer	CCLE	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.A457V	NCI-H2081	lung	COSMIC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.V442F	ACH-001024	Skin Cancer	CCLE	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1111
p.V442F	ACH-001024	Skin Cancer	CCLE	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.V442F	CHL-1	skin	COSMIC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.1111
p.V442F	CHL-1	skin	COSMIC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.S452P	ACH-001642	Lymphoma	CCLE	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.S452P	SCC-3	haematopoietic and lymphoid tissue	COSMIC	PWTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.R425L	ACH-001674	Neuroblastoma	CCLE	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.2778
p.R425L	ACH-001674	Neuroblastoma	CCLE	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0833
p.R425L	TGW	autonomic ganglia	COSMIC	PNTTPQPS	DEG_SCF_FBW7_1	427:434	Mutation rewiring degron network	0.2778
p.R425L	TGW	autonomic ganglia	COSMIC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0833
p.P412T	IMR-5	autonomic ganglia	COSMIC	PATSS	DEG_SPOP_SBC_1	412:416	Mutation altering degron motif	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD96

UniProt ID: P40200

Entrez ID: 10225

Protein name: T-cell surface protein tactile (Cell surface antigen CD96) (T cell-activated increased late expression protein) (CD antigen CD96)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CD96 in