DegronMD

Uniprot ID: P40200

Source protein: T-cell surface protein tactile

Source gene: CD96

Class: DEG_SCF_FBW7_1

Location: 427:434

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 73.3125

COIL: 0.8293

CONS_SCORE: 0.609

DSS_SCORE: 0.6233

HELIX: 0.0388

FCONS_SCORE: 1.0651

RIG_SCORE: 0.6512

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G442V	TCGA-44-2657	LUAD	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	0.1111
p.G442C	TCGA-78-7155	LUAD	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	0.1111
p.T439I	TCGA-A5-A0G2	UCEC	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	0.1944
p.S436T	TCGA-B0-5710	KIRC	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	0.2778
p.L419I	TCGA-GN-A26D	SKCM	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	0.1111
p.R441Q	TCGA-VS-A959	CESC	TCGA	PNTTPQPS	DEG_SCF_FBW7_1	0.1389
p.P417T	DO220822	BRCA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.0556
p.R444L	DO225357	BRCA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.0556
p.R425Q	DO51640	CESC	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.2778
p.S420T	DO16308	KIRC	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.1389
p.G435V	DO229018	LICA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.3056
p.S421I	DO229041	LICA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.1667
p.S433Y	DO45319	LUAD	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.712
p.G426C	DO23590	LUAD	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.3056
p.G426V	DO25020	LUAD	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.3056
p.R444Q	DO26941	LUSC	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.0556
p.S434C	DO46897	RECA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.8652
p.P430S	DO229453	SKCA	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.6752
p.G435W	DO37405	SKCM	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.3056
p.T423I	DO41235	UCEC	ICGC	PNTTPQPS	DEG_SCF_FBW7_1	0.2222
p.R441L	SIDM00324	Neuroblastoma	GDSC	PNTTPQPS	DEG_SCF_FBW7_1	0.1389
p.R441L	TGW	autonomic_ganglia	COSMIC	PNTTPQPS	DEG_SCF_FBW7_1	0.1389
p.V442F	ACH-001024	Skin Cancer	CCLE	PNTTPQPS	DEG_SCF_FBW7_1	0.1111
p.V442F	CHL-1	skin	COSMIC	PNTTPQPS	DEG_SCF_FBW7_1	0.1111
p.R425L	ACH-001674	Neuroblastoma	CCLE	PNTTPQPS	DEG_SCF_FBW7_1	0.2778
p.R425L	TGW	autonomic_ganglia	COSMIC	PNTTPQPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40200	T-cell surface protein tactile	DEG_SCF_FBW7_1	427:434	PNTTPQPS	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons