DegronMD

Uniprot ID: Q9NWQ4

Source protein: G patch domain-containing protein 2-like

Source gene: GPATCH2L

Class: DEG_APCC_KENBOX_2

Location: 171:175

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9247

ASA_SCORE: 104.9

COIL: 0.796

CONS_SCORE: 0.6735

DSS_SCORE: 0.4743

HELIX: 0.1684

FCONS_SCORE: 1.2278

RIG_SCORE: 0.7287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R170S	TCGA-55-6979	LUAD	TCGA	WKENT	DEG_APCC_KENBOX_2	0.3056
p.R170S	DO24110	LUAD	ICGC	WKENT	DEG_APCC_KENBOX_2	0.3056
p.Q166H	TCGA-55-7994	LUAD	TCGA	WKENT	DEG_APCC_KENBOX_2	0.1944
p.Q166H	DO45311	LUAD	ICGC	WKENT	DEG_APCC_KENBOX_2	0.1944
p.K161E	TCGA-AB-2826	LAML	TCGA	WKENT	DEG_APCC_KENBOX_2	0.1667
p.K161E	DO21833	LAML	ICGC	WKENT	DEG_APCC_KENBOX_2	0.1667
p.R167H	TCGA-AJ-A3EL	UCEC	TCGA	WKENT	DEG_APCC_KENBOX_2	0.2222
p.R167H	DO41542	UCEC	ICGC	WKENT	DEG_APCC_KENBOX_2	0.2222
p.E173D	DO48446	BLCA	ICGC	WKENT	DEG_APCC_KENBOX_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NWQ4	G patch domain-containing protein 2-like	DEG_APCC_KENBOX_2	171:175	WKENT	APC,CDC20,FZR1	0.9247	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons