DegronMD

Uniprot ID: Q96QB1

Source protein: Rho GTPase-activating protein 7

Source gene: DLC1

Class: DEG_SCF_TRCP1_1

Location: 985:991

E3 ligase: BTRC

DEGRON score: 0.9965

ASA_SCORE: 64.9429

COIL: 0.8437

CONS_SCORE: 0.378

DSS_SCORE: 0.6619

HELIX: 0.081

FCONS_SCORE: 1.0003

RIG_SCORE: 0.6095

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R994M	TCGA-44-7670	LUAD	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.25
p.R994M	DO23555	LUAD	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.25
p.G987V	TCGA-86-8358	LUAD	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.7532
p.G987V	DO25471	LUAD	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.7532
p.G987A	TCGA-A2-A0D0	BRCA	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.754
p.H998R	TCGA-B5-A11E	UCEC	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.1389
p.H998R	DO41644	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.1389
p.R984S	TCGA-CN-A63U	HNSC	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.3056
p.R984S	DO44454	HNSC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.3056
p.A990S	TCGA-D1-A163	UCEC	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.6477
p.G989V	TCGA-EE-A3AA	SKCM	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.6421
p.H985Y	DO51920	BLCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.7229
p.R994I	DO222562	MELA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.25
p.A994V	DO41752	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.25
p.H998Q	SIDM00014	Colorectal Carcinoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	0.1389
p.R1001Q	HT-115	large_intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.0556
p.P986L	SW684	soft_tissue	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.7582
p.V991A	SNU-1040	large_intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.6936
p.R1001W	SNU-1040	large_intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.0556
p.A987S	NCI-H441	lung	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92502	StAR-related lipid transfer protein 8	DEG_SCF_TRCP1_1	480:486	DSGVGAS	BTRC	0.9959	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SCF_TRCP1_1	985:991	DSGVGAS	BTRC	0.9965	More...
Q9Y3M8	StAR-related lipid transfer protein 13	DEG_SCF_TRCP1_1	571:577	DSGVGAS	BTRC	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons