DegronMD

Uniprot ID: Q92502

Source protein: StAR-related lipid transfer protein 8

Source gene: STARD8

Class: DEG_SCF_TRCP1_1

Location: 480:486

E3 ligase: BTRC

DEGRON score: 0.9959

ASA_SCORE: 66.8714

COIL: 0.8501

CONS_SCORE: 0.3349

DSS_SCORE: 0.5954

HELIX: 0.0769

FCONS_SCORE: 0.9724

RIG_SCORE: 0.6316

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A478T	TCGA-AY-A71X	COAD	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.2778
p.A482D	TCGA-IB-7651	PAAD	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.7793
p.S486L	DO48391	BLCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.8778
p.R478W	DO1668	BRCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.2778
p.R478W	DO8506	COAD	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.2778
p.D480N	DO222884	COCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.6932
p.D480N	DO10880	GBM	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.6932
p.D480N	DO37607	SKCM	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.6932
p.R476C	DO228400	MALY	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.2222
p.PR475PC	DO222875	MELA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0
p.R495C	DO37667	SKCM	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.0833
p.A485D	DO229221	THCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.6682
p.R495S	DO41572	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.0833
p.D496H	SIDM00254	Neuroblastoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	0.0556
p.D496H	SIDM00808	Burkitt's Lymphoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	0.0556
p.D496H	SIDM00760	Small Cell Lung Carcinoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	0.0556
p.D496H	SIDM01254	Burkitt's Lymphoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	0.0556
p.V477E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	0.25
p.V477E	ACH-000916	Lung Cancer	CCLE	DSGVGAS	DEG_SCF_TRCP1_1	0.25
p.V477E	NCI-H1573	lung	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.25
p.P489L	ACH-002222	Leukemia	CCLE	DSGVGAS	DEG_SCF_TRCP1_1	0.25
p.R478Q	RKO	large_intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.2778
p.R478Q	CL-40	large_intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92502	StAR-related lipid transfer protein 8	DEG_SCF_TRCP1_1	480:486	DSGVGAS	BTRC	0.9959	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SCF_TRCP1_1	985:991	DSGVGAS	BTRC	0.9965	More...
Q9Y3M8	StAR-related lipid transfer protein 13	DEG_SCF_TRCP1_1	571:577	DSGVGAS	BTRC	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons