DegronMD

Uniprot ID: Q9Y3M8

Source protein: StAR-related lipid transfer protein 13

Source gene: STARD13

Class: DEG_SCF_TRCP1_1

Location: 571:577

E3 ligase: BTRC

DEGRON score: 0.9984

ASA_SCORE: 62.0286

COIL: 0.8357

CONS_SCORE: 0.3781

DSS_SCORE: 0.6654

HELIX: 0.072

FCONS_SCORE: 1.0668

RIG_SCORE: 0.6282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V574G	TCGA-D3-A3MR	SKCM	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.6421
p.P581T	TCGA-X6-A7WA	SARC	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	0.2222
p.G578C	DO229473	LAML	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.3056
p.S571R	DO228923	LICA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.7427
p.R581H	DO220911	MELA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.2222
p.L579F	DO222413	MELA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.2778
p.D575N	DO37814	SKCM	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.6932
p.D575N	DO42280	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.6932
p.L574P	DO38619	STAD	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.7582
p.D575Y	DO229227	THCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.7325
p.S587Y	DO52412	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.0556
p.R570C	DO41235	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.3056
p.R570H	DO42673	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	0.3056
p.S561I	HT-115	large_intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.0556
p.L584P	LS-180	large_intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92502	StAR-related lipid transfer protein 8	DEG_SCF_TRCP1_1	480:486	DSGVGAS	BTRC	0.9959	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SCF_TRCP1_1	985:991	DSGVGAS	BTRC	0.9965	More...
Q9Y3M8	StAR-related lipid transfer protein 13	DEG_SCF_TRCP1_1	571:577	DSGVGAS	BTRC	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons