DegronMD - Q9Y3M8(STARD13)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P172L	TCGA-22-1011	LUSC	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.1111
p.S171L	TCGA-34-5239	LUSC	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation blocking phosphorylation signal	0.5833
p.R155L	TCGA-44-2656	LUAD	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2778
p.G170V	TCGA-50-6590	LUAD	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.1667
p.V883M	TCGA-AN-A0FS	BRCA	TCGA	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.3056
p.S154Y	TCGA-AZ-4315	COAD	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation blocking phosphorylation signal	0.6944
p.S881L	TCGA-CG-4306	STAD	TCGA	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.25
p.R879H	TCGA-CM-4751	COAD	TCGA	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.1944
p.L163I	TCGA-D1-A103	UCEC	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.6063
p.R151C	TCGA-D1-A16X	UCEC	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.1667
p.L895F	TCGA-D3-A1QA	SKCM	TCGA	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.25
p.V574G	TCGA-D3-A3MR	SKCM	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.6421
p.L162M	TCGA-DD-AACB	LIHC	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.5999
p.G166R	TCGA-EE-A181	SKCM	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2778
p.L895V	TCGA-EY-A1GI	UCEC	TCGA	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.25
p.R165Q	TCGA-FD-A5BT	BLCA	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.3056
p.R165Q	SIDM00118	Colorectal Carcinoma	GDSC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.3056
p.R165Q	ACH-001081	Colon/Colorectal Cancer	CCLE	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.3056
p.R165Q	HCC2998	large intestine	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.3056
p.R155C	TCGA-FR-A726	SKCM	TCGA	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2778
p.A876G	TCGA-R6-A6L6	ESCA	TCGA	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.1111
p.E900K	TCGA-WE-AAA0	SKCM	TCGA	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.1111
p.P581T	TCGA-X6-A7WA	SARC	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.2222
p.R879G	TCGA-ZC-AAA7	THYM	TCGA	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.1944
p.T902A	DO8490	COAD	ICGC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.0556
p.Q880L	DO219922	DLBC	ICGC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.2222
p.L883R	DO233888	GACA	ICGC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.3056
p.G161W	DO52050	HNSC	ICGC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.7825
p.G578C	DO229473	LAML	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.3056
p.S571R	DO228923	LICA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.7427
p.A887D	DO229028	LICA	ICGC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation altering degron motif	0.7793
p.T876K	DO229031	LICA	ICGC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.1111
p.T876I	DO23681	LUAD	ICGC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.1111
p.R162L	DO26052	LUAD	ICGC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.8428
p.A153D	DO26544	LUSC	ICGC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2222
p.G150E	DO219144	LUSC	ICGC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.1389
p.R581H	DO220911	MELA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.2222
p.L579F	DO222413	MELA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.2778
p.S160F	DO28249	OV	ICGC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.7982
p.M886I	DO51171	PAEN	ICGC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation altering degron motif	0.7618
p.D575N	DO37814	SKCM	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.6932
p.D575N	DO42280	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.6932
p.H889N	DO37405	SKCM	ICGC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation altering degron motif	0.7423
p.H889N	DO37971	SKCM	ICGC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation altering degron motif	0.7423
p.L574P	DO38619	STAD	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.7582
p.D575Y	DO229227	THCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.7325
p.G164C	DO42033	UCEC	ICGC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.76
p.G164C	22RV1	prostate	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.76
p.G164C	NCI-SNU-1	stomach	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.76
p.S587Y	DO52412	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.0556
p.R570C	DO41235	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.3056
p.R570H	DO42673	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.3056
p.T161M	SIDM00108	Melanoma	GDSC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.8534
p.T161M	UACC-257	skin	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.8534
p.V889M	SIDM00967	Ovarian Carcinoma	GDSC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation altering degron motif	0.7208
p.G174C	SIDM00781	Colorectal Carcinoma	GDSC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.0556
p.G174C	SIDM00780	Colorectal Carcinoma	GDSC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.0556
p.G174C	ACH-000967	Colon/Colorectal Cancer	CCLE	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.0556
p.G174C	ACH-001199	Colon/Colorectal Cancer	CCLE	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.0556
p.G174C	SNU-C2B	large intestine	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.0556
p.G166E	SIDM00140	Melanoma	GDSC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2778
p.G166E	ACH-000968	Skin Cancer	CCLE	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2778
p.G166E	COLO-792	skin	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2778
p.E884G	ACH-001274	Sarcoma	CCLE	EAEIHVPTL	DEG_COP1_1	884:892	Mutation altering degron motif	0.7199
p.T153M	UACC-257	skin	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2222
p.G155R	LOU-NH91	lung	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2778
p.S561I	HT-115	large intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.0556
p.R157Q	HCC2998	large intestine	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.7329
p.G158E	COLO-792	skin	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation altering degron motif	0.7199
p.G895V	NCI-H2141	lung	COSMIC	EAEIHVPTL	DEG_COP1_1	884:892	Mutation rewiring degron network	0.25
p.G166C	SNU-C2B	large intestine	COSMIC	DDLYTLLP	CBL_PTK	157:164	Mutation rewiring degron network	0.2778
p.L584P	LS-180	large intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STARD13

UniProt ID: Q9Y3M8

Entrez ID: 90627

Protein name: StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for STARD13 in