DegronMD

Uniprot ID: Q9Y3M8

Source protein: StAR-related lipid transfer protein 13

Source gene: STARD13

Class: CBL_PTK

Location: 157:164

E3 ligase: CBL

DEGRON score: 0.8838

ASA_SCORE: 77.375

COIL: 0.7429

CONS_SCORE: 0.3543

DSS_SCORE: 0.4238

HELIX: 0.1776

FCONS_SCORE: 0.8289

RIG_SCORE: 0.8359

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P172L	TCGA-22-1011	LUSC	TCGA	DDLYTLLP	CBL_PTK	0.1111
p.S171L	TCGA-34-5239	LUSC	TCGA	DDLYTLLP	CBL_PTK	0.5833
p.R155L	TCGA-44-2656	LUAD	TCGA	DDLYTLLP	CBL_PTK	0.2778
p.G170V	TCGA-50-6590	LUAD	TCGA	DDLYTLLP	CBL_PTK	0.1667
p.S154Y	TCGA-AZ-4315	COAD	TCGA	DDLYTLLP	CBL_PTK	0.6944
p.L163I	TCGA-D1-A103	UCEC	TCGA	DDLYTLLP	CBL_PTK	0.6063
p.R151C	TCGA-D1-A16X	UCEC	TCGA	DDLYTLLP	CBL_PTK	0.1667
p.L162M	TCGA-DD-AACB	LIHC	TCGA	DDLYTLLP	CBL_PTK	0.5999
p.G166R	TCGA-EE-A181	SKCM	TCGA	DDLYTLLP	CBL_PTK	0.2778
p.R165Q	TCGA-FD-A5BT	BLCA	TCGA	DDLYTLLP	CBL_PTK	0.3056
p.R165Q	SIDM00118	Colorectal Carcinoma	GDSC	DDLYTLLP	CBL_PTK	0.3056
p.R165Q	ACH-001081	Colon/Colorectal Cancer	CCLE	DDLYTLLP	CBL_PTK	0.3056
p.R165Q	HCC2998	large_intestine	COSMIC	DDLYTLLP	CBL_PTK	0.3056
p.R155C	TCGA-FR-A726	SKCM	TCGA	DDLYTLLP	CBL_PTK	0.2778
p.G161W	DO52050	HNSC	ICGC	DDLYTLLP	CBL_PTK	0.7825
p.R162L	DO26052	LUAD	ICGC	DDLYTLLP	CBL_PTK	0.8428
p.A153D	DO26544	LUSC	ICGC	DDLYTLLP	CBL_PTK	0.2222
p.G150E	DO219144	LUSC	ICGC	DDLYTLLP	CBL_PTK	0.1389
p.S160F	DO28249	OV	ICGC	DDLYTLLP	CBL_PTK	0.7982
p.G164C	DO42033	UCEC	ICGC	DDLYTLLP	CBL_PTK	0.76
p.G164C	22RV1	prostate	COSMIC	DDLYTLLP	CBL_PTK	0.76
p.G164C	NCI-SNU-1	stomach	COSMIC	DDLYTLLP	CBL_PTK	0.76
p.T161M	SIDM00108	Melanoma	GDSC	DDLYTLLP	CBL_PTK	0.8534
p.T161M	UACC-257	skin	COSMIC	DDLYTLLP	CBL_PTK	0.8534
p.G174C	SIDM00781	Colorectal Carcinoma	GDSC	DDLYTLLP	CBL_PTK	0.0556
p.G174C	SIDM00780	Colorectal Carcinoma	GDSC	DDLYTLLP	CBL_PTK	0.0556
p.G174C	ACH-000967	Colon/Colorectal Cancer	CCLE	DDLYTLLP	CBL_PTK	0.0556
p.G174C	ACH-001199	Colon/Colorectal Cancer	CCLE	DDLYTLLP	CBL_PTK	0.0556
p.G174C	SNU-C2B	large_intestine	COSMIC	DDLYTLLP	CBL_PTK	0.0556
p.G166E	SIDM00140	Melanoma	GDSC	DDLYTLLP	CBL_PTK	0.2778
p.G166E	ACH-000968	Skin Cancer	CCLE	DDLYTLLP	CBL_PTK	0.2778
p.G166E	COLO-792	skin	COSMIC	DDLYTLLP	CBL_PTK	0.2778
p.T153M	UACC-257	skin	COSMIC	DDLYTLLP	CBL_PTK	0.2222
p.G155R	LOU-NH91	lung	COSMIC	DDLYTLLP	CBL_PTK	0.2778
p.R157Q	HCC2998	large_intestine	COSMIC	DDLYTLLP	CBL_PTK	0.7329
p.G158E	COLO-792	skin	COSMIC	DDLYTLLP	CBL_PTK	0.7199
p.G166C	SNU-C2B	large_intestine	COSMIC	DDLYTLLP	CBL_PTK	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DDLYTLLP

Degron related mutations and impact score

Drug responses associated with STARD13 mutations

All proteins holding degron of DDLYTLLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3M8	StAR-related lipid transfer protein 13	CBL_PTK	157:164	DDLYTLLP	CBL	0.8838	More...