DegronMD - Q92502(STARD8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K98N	TCGA-66-2786	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.6918
p.H94N	TCGA-80-5608	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2222
p.E104Q	TCGA-98-8021	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2778
p.S53L	TCGA-A5-A0G2	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1111
p.S53L	TCGA-AA-A010	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1111
p.N64K	TCGA-A5-A2K5	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	61:65	Mutation altering degron motif	0.6918
p.N64K	TCGA-B5-A11E	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	61:65	Mutation altering degron motif	0.6918
p.N64K	DO41644	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	61:65	Mutation altering degron motif	0.6918
p.N64K	DO41379	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	61:65	Mutation altering degron motif	0.6918
p.L132M	TCGA-AP-A1DV	UCEC	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.711
p.S125Y	TCGA-AP-A1E0	UCEC	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.3056
p.S130F	TCGA-AX-A1CE	UCEC	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.7982
p.A478T	TCGA-AY-A71X	COAD	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.2778
p.P55S	TCGA-BR-8680	STAD	TCGA	PATSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1667
p.P55S	DO47769	STAD	ICGC	PATSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1667
p.A142V	TCGA-D3-A8GM	SKCM	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1111
p.C123F	TCGA-DX-A6YV	SARC	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.W455R	TCGA-EY-A215	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.T110A	TCGA-FI-A2D5	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1111
p.S442T	TCGA-IB-7651	PAAD	TCGA	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.25
p.A482D	TCGA-IB-7651	PAAD	TCGA	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation altering degron motif	0.7793
p.S486L	DO48391	BLCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation altering degron motif	0.8778
p.E67K	DO44032	BLCA	ICGC	PATSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2778
p.R123C	DO225079	BRCA	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.R123C	DO52402	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.S447F	DO1116	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7982
p.R478W	DO1668	BRCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.2778
p.R478W	DO8506	COAD	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.2778
p.Q111H	DO4928	BRCA	ICGC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0833
p.R127H	DO222421	BTCA	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.8244
p.D480N	DO222884	COCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation altering degron motif	0.6932
p.D480N	DO10880	GBM	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation altering degron motif	0.6932
p.D480N	DO37607	SKCM	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation altering degron motif	0.6932
p.N456S	DO233283	GACA	ICGC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1389
p.G112D	DO12286	GBM	ICGC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0556
p.G112D	DO43714	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0556
p.S128I	DO228952	LICA	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.623
p.R125L	DO229026	LICA	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.3056
p.D69E	DO229051	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2222
p.L92F	DO50868	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1667
p.K141R	DO52210	LIHC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation substituting flanking lysine	0.25
p.A446D	DO24275	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.6682
p.P95Q	DO25426	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.25
p.S442C	DO25350	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.25
p.R97C	DO45364	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.3056
p.D452E	DO26461	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.25
p.R476C	DO228400	MALY	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.2222
p.PR475PC	DO222875	MELA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0
p.R125H	DO32698	OV	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.3056
p.N456K	DO28009	OV	ICGC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1389
p.R104Q	DO36238	PRAD	ICGC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2778
p.S108I	DO37651	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation blocking phosphorylation signal	0.6111
p.R495C	DO37667	SKCM	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.0833
p.R127S	DO37703	SKCM	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.7427
p.G438R	DO37406	SKCM	ICGC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1389
p.A62V	DO50288	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	61:65	Mutation altering degron motif	0.5825
p.P116T	DO38039	SKCM	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.0556
p.E450K	DO38001	SKCM	ICGC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.E450K	DO43041	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.E88K	DO38423	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0556
p.A485D	DO229221	THCA	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation altering degron motif	0.6682
p.K121N	DO219773	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation substituting flanking lysine	0.3056
p.R125C	DO43682	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.3056
p.L52M	DO43186	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.0833
p.R495S	DO41572	UCEC	ICGC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.0833
p.S144R	DO41999	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.0556
p.C66Y	DO41999	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.3056
p.Q117R	DO41871	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.0833
p.W455C	SIDM02021	Esophageal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.D496H	SIDM00254	Neuroblastoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.0556
p.D496H	SIDM00808	Burkitt's Lymphoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.0556
p.D496H	SIDM00760	Small Cell Lung Carcinoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.0556
p.D496H	SIDM01254	Burkitt's Lymphoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.0556
p.V477E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.25
p.V477E	ACH-000916	Lung Cancer	CCLE	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.25
p.V477E	NCI-H1573	lung	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.25
p.S88L	SIDM00118	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0556
p.S88L	ACH-001081	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0556
p.S88L	HCC2998	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0556
p.P489L	ACH-002222	Leukemia	CCLE	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.25
p.R478Q	RKO	large intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.2778
p.R478Q	CL-40	large intestine	COSMIC	DSGVGAS	DEG_SCF_TRCP1_1	480:486	Mutation rewiring degron network	0.2778
p.P89L	MCC13	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STARD8

UniProt ID: Q92502

Entrez ID: 9754

Protein name: StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STARD8 in