DegronMD

Uniprot ID: Q92502

Source protein: StAR-related lipid transfer protein 8

Source gene: STARD8

Class: DEG_APCC_DBOX_1

Location: 126:134

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7403

ASA_SCORE: 93.5444

COIL: 0.1713

CONS_SCORE: 0.3728

DSS_SCORE: 0.7457

HELIX: 0.8258

FCONS_SCORE: 1.1001

RIG_SCORE: 0.6967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L132M	TCGA-AP-A1DV	UCEC	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	0.711
p.S125Y	TCGA-AP-A1E0	UCEC	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	0.3056
p.S130F	TCGA-AX-A1CE	UCEC	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	0.7982
p.A142V	TCGA-D3-A8GM	SKCM	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	0.1111
p.C123F	TCGA-DX-A6YV	SARC	TCGA	NRSFLKHLE	DEG_APCC_DBOX_1	0.25
p.R123C	DO225079	BRCA	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.25
p.R123C	DO52402	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.25
p.R127H	DO222421	BTCA	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.8244
p.S128I	DO228952	LICA	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.623
p.R125L	DO229026	LICA	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.3056
p.K141R	DO52210	LIHC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.25
p.R125H	DO32698	OV	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.3056
p.R127S	DO37703	SKCM	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.7427
p.P116T	DO38039	SKCM	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.0556
p.K121N	DO219773	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.3056
p.R125C	DO43682	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.3056
p.S144R	DO41999	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.0556
p.Q117R	DO41871	UCEC	ICGC	NRSFLKHLE	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92502	StAR-related lipid transfer protein 8	DEG_APCC_DBOX_1	126:134	NRSFLKHLE	APC,CDC20,FZR1	0.7403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons