DegronMD

Uniprot ID: Q96QB1

Source protein: Rho GTPase-activating protein 7

Source gene: DLC1

Class: LIG_APCC_ABBA_1

Location: 772:777

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5395

ASA_SCORE: 57.9333

COIL: 0.563

CONS_SCORE: 0.3461

DSS_SCORE: 0.303

HELIX: 0.1487

FCONS_SCORE: 0.9812

RIG_SCORE: 0.7986

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q784E	TCGA-13-0921	OV	TCGA	VGMYLE	LIG_APCC_ABBA_1	0.1389
p.Q784E	DO30230	OV	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1389
p.M774K	TCGA-46-3768	LUSC	TCGA	VGMYLE	LIG_APCC_ABBA_1	0.8062
p.S766N	TCGA-AA-3715	COAD	TCGA	VGMYLE	LIG_APCC_ABBA_1	0.6111
p.S766N	DO8018	COAD	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.6111
p.S764R	TCGA-F1-6874	STAD	TCGA	VGMYLE	LIG_APCC_ABBA_1	0.5556
p.A767V	TCGA-F4-6703	COAD	TCGA	VGMYLE	LIG_APCC_ABBA_1	0.1944
p.D780Y	TCGA-O2-A5IB	LUSC	TCGA	VGMYLE	LIG_APCC_ABBA_1	0.25
p.D780Y	SIDM00660	Colorectal Carcinoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	0.25
p.D780Y	ACH-000985	Colon/Colorectal Cancer	CCLE	VGMYLE	LIG_APCC_ABBA_1	0.25
p.D780Y	LS-411N	large_intestine	COSMIC	VGMYLE	LIG_APCC_ABBA_1	0.25
p.R783H	DO1162	BRCA	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.R783H	DO43755	UCEC	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.R783C	DO222762	COCA	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.R783C	DO47769	STAD	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.Q765H	DO17492	KIRC	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1389
p.N781K	DO228976	LICA	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.2222
p.F782L	DO229038	LICA	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1944
p.E777K	DO26506	LUSC	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.7022
p.P785T	DO37431	SKCM	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1111
p.Q782H	DO47578	SKCM	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1944
p.L767M	DO39552	THCA	ICGC	VGMYLE	LIG_APCC_ABBA_1	0.1944
p.N783S	SIDM00086	Kidney Carcinoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.N783S	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.N783S	SIDM00209	Glioblastoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.N783S	D-423MG	central_nervous_system	COSMIC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.N783S	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.N783K	SIDM00120	Prostate Carcinoma	GDSC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.N783K	ACH-000979	Prostate Cancer	CCLE	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.N783K	DU-145	prostate	COSMIC	VGMYLE	LIG_APCC_ABBA_1	0.1667
p.A782V	KM12	large_intestine	COSMIC	VGMYLE	LIG_APCC_ABBA_1	0.1944
p.C769Y	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	VGMYLE	LIG_APCC_ABBA_1	0.25
p.P776S	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	VGMYLE	LIG_APCC_ABBA_1	0.6752
p.K784T	HCT-15	large_intestine	COSMIC	VGMYLE	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGMYLE

Degron related mutations and impact score

Drug responses associated with DLC1 mutations

All proteins holding degron of VGMYLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QB1	Rho GTPase-activating protein 7	LIG_APCC_ABBA_1	772:777	VGMYLE	APC,CDC20,FZR1	0.5395	More...