DegronMD

Uniprot ID: Q96QB1

Source protein: Rho GTPase-activating protein 7

Source gene: DLC1

Class: DEG_APCC_DBOX_1

Location: 664:672

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9879

ASA_SCORE: 81.4778

COIL: 0.2078

CONS_SCORE: 0.4514

DSS_SCORE: 0.568

HELIX: 0.7802

FCONS_SCORE: 1.2217

RIG_SCORE: 0.7516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K677N	TCGA-58-A46M	LUSC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.3056
p.H680N	TCGA-63-A5MI	LUSC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.1111
p.R665C	TCGA-AA-3949	COAD	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.8301
p.T664M	TCGA-AX-A06F	UCEC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.6312
p.R665H	TCGA-AX-A2HD	UCEC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.8244
p.S682N	TCGA-B5-A11J	UCEC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.0556
p.G655C	TCGA-BR-8591	STAD	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.0833
p.G655C	DO47973	STAD	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	0.0833
p.E657K	TCGA-CI-6620	READ	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.1389
p.E657K	DO36825	READ	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	0.1389
p.S679C	TCGA-D6-8568	HNSC	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.1389
p.R670P	TCGA-HT-8011	LGG	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.6401
p.R670P	DO22197	LGG	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	0.6401
p.K675R	TCGA-IB-7651	PAAD	TCGA	TRSLLKRME	DEG_APCC_DBOX_1	0.3611
p.D671E	DO8264	COAD	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	0.6758
p.S678N	DO230342	COCA	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	0.1667
p.R666Q	DO233154	GACA	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	0.7329
p.S679L	DO232761	PBCA	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	0.1389
p.S679L	DO36556	READ	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	0.1389
p.R663Q	DO42713	UCEC	ICGC	TRSLLKRME	DEG_APCC_DBOX_1	0.3056
p.K676T	HCT-15	large_intestine	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	0.2222
p.A674V	KM12	large_intestine	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	0.2778
p.C669Y	CAL-12T	lung	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	0.7087
p.A654D	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	0.1667
p.H668R	OVISE	ovary	COSMIC	TRSLLKRME	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QB1	Rho GTPase-activating protein 7	DEG_APCC_DBOX_1	664:672	TRSLLKRME	APC,CDC20,FZR1	0.9879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons