DegronMD

Uniprot ID: Q7Z6Z7

Source protein: E3 ubiquitin-protein ligase HUWE1

Source gene: HUWE1

Class: DEG_SCF_FBW7_1

Location: 2745:2751

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 81.8857

COIL: 0.9341

CONS_SCORE: 0.3451

DSS_SCORE: 0.7936

HELIX: 0.0469

FCONS_SCORE: 1.0783

RIG_SCORE: 0.5774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2752H	TCGA-85-A4CL	LUSC	TCGA	PTTPSST	DEG_SCF_FBW7_1	0.3056
p.D2752H	DO45454	LUSC	ICGC	PTTPSST	DEG_SCF_FBW7_1	0.3056
p.K2759N	TCGA-AP-A0LM	UCEC	TCGA	PTTPSST	DEG_SCF_FBW7_1	0.2222
p.K2759N	DO43306	UCEC	ICGC	PTTPSST	DEG_SCF_FBW7_1	0.2222
p.G2737W	TCGA-D3-A2JN	SKCM	TCGA	PTTPSST	DEG_SCF_FBW7_1	0.1111
p.G2737W	TCGA-DA-A1I7	SKCM	TCGA	PTTPSST	DEG_SCF_FBW7_1	0.1111
p.G2737W	TCGA-EE-A3AG	SKCM	TCGA	PTTPSST	DEG_SCF_FBW7_1	0.1111
p.G2737W	DO37471	SKCM	ICGC	PTTPSST	DEG_SCF_FBW7_1	0.1111
p.G2737W	DO37951	SKCM	ICGC	PTTPSST	DEG_SCF_FBW7_1	0.1111
p.G2737W	DO47590	SKCM	ICGC	PTTPSST	DEG_SCF_FBW7_1	0.1111
p.A2753T	TCGA-EC-A24G	UCEC	TCGA	PTTPSST	DEG_SCF_FBW7_1	0.2778
p.A2753T	DO40996	UCEC	ICGC	PTTPSST	DEG_SCF_FBW7_1	0.2778
p.G2737V	TCGA-G7-6797	KIRP	TCGA	PTTPSST	DEG_SCF_FBW7_1	0.1111
p.G2737V	DO20917	KIRP	ICGC	PTTPSST	DEG_SCF_FBW7_1	0.1111
p.P2739L	TCGA-L9-A444	LUAD	TCGA	PTTPSST	DEG_SCF_FBW7_1	0.1667
p.P2739L	DO26015	LUAD	ICGC	PTTPSST	DEG_SCF_FBW7_1	0.1667
p.A2754D	DO229006	LICA	ICGC	PTTPSST	DEG_SCF_FBW7_1	0.25
p.G2754D	AN3-CA	endometrium	COSMIC	PTTPSST	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60885	Bromodomain-containing protein 4	DEG_SCF_FBW7_1	1210:1216	PTTPSST	FBXW7	0.9955	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SCF_FBW7_1	2745:2751	PTTPSST	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons