DegronMD

Uniprot ID: O14974

Source protein: Protein phosphatase 1 regulatory subunit 12A

Source gene: PPP1R12A

Class: DEG_SPOP_SBC_1

Location: 567:571

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 97.54

COIL: 0.9624

CONS_SCORE: 0.3623

DSS_SCORE: 0.5009

HELIX: 0.0142

FCONS_SCORE: 1.0853

RIG_SCORE: 0.6396

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V570A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.6936
p.P568S	TCGA-A5-A1OF	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.5641
p.P568S	DO42568	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.5641
p.S565C	TCGA-FJ-A3Z7	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2778
p.S565C	DO463	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.S565C	SIDM00845	Burkitt's Lymphoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.S565C	SIDM00461	Acute Myeloid Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.S565C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.S565C	SIDM01519	Head and Neck Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.S565C	ACH-000786	Lymphoma	CCLE	VPSTT	DEG_SPOP_SBC_1	0.2778
p.S565C	ACH-000992	Head and Neck Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.2778
p.T563A	MFE-319	endometrium	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.T563N	LNCaP-Clone-FGC	prostate	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.L562V	TCGA-EY-A1GI	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1944
p.L562V	DO41211	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.A580D	DO229025	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0833
p.R557K	TCGA-XF-AAN2	BLCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.0556
p.R557K	DO219052	BLCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.L557S	SK-UT-1	soft_tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

Showing 1 to 11 of 11 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons