DegronMD

Uniprot ID: Q8NEV8

Source protein: Exophilin-5

Source gene: EXPH5

Class: DEG_SPOP_SBC_1

Location: 900:904

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 82.42

COIL: 0.9364

CONS_SCORE: 0.9615

DSS_SCORE: 0.6025

HELIX: 0.0306

FCONS_SCORE: 1.2561

RIG_SCORE: 0.668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P901L	TCGA-AO-A0JA	BRCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.6471
p.F906L	TCGA-BP-5182	KIRC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2778
p.S902T	TCGA-BR-7723	STAD	TCGA	VPSTT	DEG_SPOP_SBC_1	0.7116
p.D896G	TCGA-C8-A8HR	BRCA	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2222
p.P911L	TCGA-D3-A8GR	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1389
p.N891I	DO7798	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.T912A	DO50388	ESAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.R910I	DO10880	GBM	ICGC	VPSTT	DEG_SPOP_SBC_1	0.6111
p.S898L	DO26578	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.E892D	DO51124	PRAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.S902P	SIDM00879	Breast Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.7863
p.S902P	ACH-000349	Breast Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.7863
p.S902P	HCC1500	breast	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.7863
p.V905M	ACH-001369	Ovarian Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.3056
p.S895P	HCC1500	breast	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons