DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_SPOP_SBC_1

Location: 675:679

E3 ligase: SPOP

DEGRON score: 0.8249

ASA_SCORE: 83.06

COIL: 0.8944

CONS_SCORE: 0.7852

DSS_SCORE: 0.3448

HELIX: 0.0296

FCONS_SCORE: 1.013

RIG_SCORE: 0.7663

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L673M	TCGA-05-4396	LUAD	TCGA	VPSTT	DEG_SPOP_SBC_1	0.2778
p.L673M	DO23838	LUAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.P676S	TCGA-AA-3672	COAD	TCGA	VPSTT	DEG_SPOP_SBC_1	0.5641
p.P676S	DO9010	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	0.5641
p.S670L	TCGA-AP-A0LM	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.1944
p.S670L	DO43306	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.S670L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	0.1944
p.S670L	ACH-000920	Leukemia	CCLE	VPSTT	DEG_SPOP_SBC_1	0.1944
p.S677L	TCGA-HT-8564	LGG	TCGA	VPSTT	DEG_SPOP_SBC_1	0.7667
p.S677L	DO44623	LGG	ICGC	VPSTT	DEG_SPOP_SBC_1	0.7667
p.N685S	DO233734	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.1667
p.S665A	DO49533	LAML	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.S665A	DO231260	LAML	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0556
p.Q671H	DO229029	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2222
p.T678M	SIDM00611	Kidney Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.7423
p.T678M	ACH-000684	Kidney Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.7423
p.T678M	KMRC-1	kidney	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.7423
p.V675A	SIDM01248	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.5825
p.V675A	SIDM01167	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.5825
p.V675A	ACH-000163	Thyroid Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.5825
p.V675A	ACH-001023	Thyroid Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.5825
p.V675A	CGTH-W-1	thyroid	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.5825
p.M667I	SIDM00188	Kidney Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	0.1111
p.M667I	ACH-002139	Kidney Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	0.1111
p.M667I	HA7-RCC	kidney	COSMIC	VPSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons