DegronMD

Uniprot ID: Q14686

Source protein: Nuclear receptor coactivator 6

Source gene: NCOA6

Class: DEG_SPOP_SBC_1

Location: 533:537

E3 ligase: SPOP

DEGRON score: 0.9759

ASA_SCORE: 94.18

COIL: 0.9646

CONS_SCORE: 0.6835

DSS_SCORE: 0.7213

HELIX: 0.0148

FCONS_SCORE: 1.0783

RIG_SCORE: 0.6594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S535L	TCGA-A5-A0GP	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.7667
p.S535L	TCGA-DG-A2KL	CESC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.7667
p.S535L	TCGA-FW-A3R5	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	0.7667
p.S535L	DO51596	CESC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.7667
p.S535L	DO37406	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	0.7667
p.S535L	DO41109	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.7667
p.V533M	TCGA-B5-A1MX	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	0.7208
p.V533M	DO41999	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	0.7208
p.G531S	DO229325	BTCA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.2778
p.A546D	DO229034	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	567:571	VPSTT	SPOP	0.9968	More...
O15020	Spectrin beta chain, non-erythrocytic 2	DEG_SPOP_SBC_1	2342:2346	VPSTT	SPOP	0.9599	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	566:570	VPSTT	SPOP	0.7372	More...
P18583	Protein SON	DEG_SPOP_SBC_1	675:679	VPSTT	SPOP	0.8249	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	193:197	VPSTT	SPOP	0.9767	More...
Q13123	Protein Red	DEG_SPOP_SBC_1	326:330	VPSTT	SPOP	0.9958	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	533:537	VPSTT	SPOP	0.9759	More...
Q1W6H9	Protein FAM110C	DEG_SPOP_SBC_1	280:284	VPSTT	SPOP	0.9945	More...
Q8NEV8	Exophilin-5	DEG_SPOP_SBC_1	900:904	VPSTT	SPOP	0.9989	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	471:475	VPSTT	SPOP	0.9983	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1004:1008	VPSTT	SPOP	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons