DegronMD

Uniprot ID: O14974

Source protein: Protein phosphatase 1 regulatory subunit 12A

Source gene: PPP1R12A

Class: DEG_SPOP_SBC_1

Location: 771:775

E3 ligase: SPOP

DEGRON score: 0.9914

ASA_SCORE: 90.56

COIL: 0.933

CONS_SCORE: 0.3488

DSS_SCORE: 0.5595

HELIX: 0.0354

FCONS_SCORE: 1.103

RIG_SCORE: 0.6598

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q767R	TCGA-63-A5ML	LUSC	TCGA	PVSTS	DEG_SPOP_SBC_1	0.2222
p.Q767R	DO219151	LUSC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.2222
p.T761M	TCGA-B5-A3FC	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	0.5
p.T761M	TCGA-D1-A103	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	0.5
p.T761M	DO42312	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.5
p.T761M	DO41871	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.5
p.R768H	DO229389	BTCA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.25
p.E764K	DO14566	HNSC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.P771Q	DO228952	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.7035
p.T765N	DO228974	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.6111
p.P780S	DO220879	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1944
p.T779A	SIDM00625	Other Sarcomas	GDSC	PVSTS	DEG_SPOP_SBC_1	0.2222
p.T779A	MES-SA	soft_tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	0.2222
p.Q767H	SIDM00885	Breast Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	0.2222
p.Q767H	ACH-000111	Breast Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	0.2222
p.Q767H	HCC1187	breast	COSMIC	PVSTS	DEG_SPOP_SBC_1	0.2222
p.R764K	8-MG-BA	central_nervous_system	COSMIC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.R764K	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L390	Pleckstrin homology domain-containing family G member 3	DEG_SPOP_SBC_1	2:6	PVSTS	SPOP	0.7869	More...
O14836	Tumor necrosis factor receptor superfamily member 13B	DEG_SPOP_SBC_1	219:223	PVSTS	SPOP	0.8996	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	771:775	PVSTS	SPOP	0.9914	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	339:343	PVSTS	SPOP	0.933	More...
P07333	Macrophage colony-stimulating factor 1 receptor	DEG_SPOP_SBC_1	728:732	PVSTS	SPOP	0.9843	More...
P07947	Tyrosine-protein kinase Yes	DEG_SPOP_SBC_1	24:28	PVSTS	SPOP	0.9939	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	4012:4016	PVSTS	SPOP	0.5207	More...
Q06187	Tyrosine-protein kinase BTK	DEG_SPOP_SBC_1	210:214	PVSTS	SPOP	0.968	More...
Q13492	Phosphatidylinositol-binding clathrin assembly protein	DEG_SPOP_SBC_1	360:364	PVSTS	SPOP	0.9979	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	1654:1658	PVSTS	SPOP	0.91	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1095:1099	PVSTS	SPOP	0.9912	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	616:620	PVSTS	SPOP	0.991	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	618:622	PVSTS	SPOP	0.911	More...
Q8N3J3	Homologous recombination OB-fold protein	DEG_SPOP_SBC_1	103:107	PVSTS	SPOP	0.857	More...
Q8NFM4	Adenylate cyclase type 4	DEG_SPOP_SBC_1	500:504	PVSTS	SPOP	0.7358	More...
Q96JG6	Syndetin	DEG_SPOP_SBC_1	503:507	PVSTS	SPOP	0.9603	More...
Q8N8K9	Uncharacterized protein KIAA1958	DEG_SPOP_SBC_1	311:315	PVSTS	SPOP	0.9956	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	911:915	PVSTS	SPOP	0.8934	More...
A6NCI8	Uncharacterized protein C2orf78	DEG_SPOP_SBC_1	261:265	PVSTS	SPOP	0.9843	More...
Q2M3A8	Putative uncharacterized protein MRGPRG-AS1	DEG_SPOP_SBC_1	84:88	PVSTS	SPOP	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTS

Degron related mutations and impact score

Drug responses associated with PPP1R12A mutations

All proteins holding degron of PVSTS