DegronMD - A1L390(PLEKHG3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R15Q	TCGA-21-1080	LUSC	TCGA	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.R15Q	DO26502	LUSC	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.S12G	TCGA-50-5066	LUAD	TCGA	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.S12G	DO25040	LUAD	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.R880Q	TCGA-AX-A1CE	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.0556
p.R753C	TCGA-BR-4256	STAD	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation blocking phosphorylation signal	0.5833
p.S12R	TCGA-CR-6484	HNSC	TCGA	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.S12R	DO15206	HNSC	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.R753H	TCGA-D1-A103	UCEC	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation blocking phosphorylation signal	0.5833
p.V866I	TCGA-D5-6927	COAD	TCGA	PESSS	DEG_SPOP_SBC_1	866:870	Mutation altering degron motif	0.7076
p.P745A	TCGA-DD-A73G	LIHC	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7503
p.P745L	TCGA-DD-A73G	LIHC	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7582
p.P746S	TCGA-EE-A2MR	SKCM	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.5641
p.V740F	TCGA-O2-A52Q	LUSC	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7068
p.S10T	DO222563	BTCA	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.2222
p.R5H	DO233821	GACA	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8244
p.D728E	DO231954	LICA	ICGC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.0556
p.G752S	DO228941	LICA	ICGC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1667
p.R737I	DO229035	LICA	ICGC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.3056
p.R15L	DO229038	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.S11F	DO45335	LUAD	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1944
p.S11F	DO220875	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1944
p.P732L	DO52365	LUSC	ICGC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1667
p.R5C	DO232761	PBCA	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8301
p.R15P	DO232952	PEME	ICGC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.P866L	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	866:870	Mutation altering degron motif	0.7582
p.P866L	ACH-000611	Lymphoma	CCLE	PESSS	DEG_SPOP_SBC_1	866:870	Mutation altering degron motif	0.7582
p.S869F	SIDM00964	Non-Cancerous	GDSC	PESSS	DEG_SPOP_SBC_1	866:870	Mutation altering degron motif	0.7982
p.S869F	ACH-001453	Prostate Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	866:870	Mutation altering degron motif	0.7982
p.S869F	ACH-001982	Metastasis	CCLE	PESSS	DEG_SPOP_SBC_1	866:870	Mutation altering degron motif	0.7982
p.S869F	BPH-1	prostate	COSMIC	PESSS	DEG_SPOP_SBC_1	866:870	Mutation altering degron motif	0.7982
p.I745V	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.5965
p.S861L	SIDM01133	Other Solid Cancers	GDSC	PESSS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1944
p.S861L	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1944
p.S861L	ACH-000925	Lung Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1944
p.S861L	ACH-002177	Lung Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1944
p.S861L	NCI-H835	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1944
p.R738C	SIDM00220	Ovarian Carcinoma	GDSC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.719
p.R738C	ACH-000962	Ovarian Cancer	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.719
p.R738C	ACH-001145	Ovarian Cancer	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.719
p.R738C	OC-314	ovary	COSMIC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.719
p.H729P	ACH-000534	Lymphoma	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.0833
p.H729P	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.0833
p.V750L	ACH-001061	Colon/Colorectal Cancer	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.2222
p.R739L	ACH-001607	Gallbladder Cancer	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.8428
p.R15T	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.G735E	Raji	haematopoietic and lymphoid tissue	COSMIC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation blocking phosphorylation signal	0.6944
p.R880W	D-502MG	central nervous system	COSMIC	PESSS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.0556
p.V857E	NCI-H82	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.0833
p.P734Q	NCI-H1573	lung	COSMIC	RRESLSYIP	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHG3

UniProt ID: A1L390

Entrez ID: 26030

Protein name: Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHG3 in