DegronMD

Uniprot ID: A1L390

Source protein: Pleckstrin homology domain-containing family G member 3

Source gene: PLEKHG3

Class: DEG_APCC_DBOX_1

Location: 738:746

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9964

ASA_SCORE: 71.6

COIL: 0.7439

CONS_SCORE: 0.3663

DSS_SCORE: 0.317

HELIX: 0.1972

FCONS_SCORE: 1.2039

RIG_SCORE: 0.755

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R753C	TCGA-BR-4256	STAD	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	0.5833
p.R753H	TCGA-D1-A103	UCEC	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	0.5833
p.P745A	TCGA-DD-A73G	LIHC	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	0.7503
p.P745L	TCGA-DD-A73G	LIHC	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	0.7582
p.P746S	TCGA-EE-A2MR	SKCM	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	0.5641
p.V740F	TCGA-O2-A52Q	LUSC	TCGA	RRESLSYIP	DEG_APCC_DBOX_1	0.7068
p.D728E	DO231954	LICA	ICGC	RRESLSYIP	DEG_APCC_DBOX_1	0.0556
p.G752S	DO228941	LICA	ICGC	RRESLSYIP	DEG_APCC_DBOX_1	0.1667
p.R737I	DO229035	LICA	ICGC	RRESLSYIP	DEG_APCC_DBOX_1	0.3056
p.P732L	DO52365	LUSC	ICGC	RRESLSYIP	DEG_APCC_DBOX_1	0.1667
p.I745V	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRESLSYIP	DEG_APCC_DBOX_1	0.5965
p.R738C	SIDM00220	Ovarian Carcinoma	GDSC	RRESLSYIP	DEG_APCC_DBOX_1	0.719
p.R738C	ACH-000962	Ovarian Cancer	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	0.719
p.R738C	ACH-001145	Ovarian Cancer	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	0.719
p.R738C	OC-314	ovary	COSMIC	RRESLSYIP	DEG_APCC_DBOX_1	0.719
p.H729P	ACH-000534	Lymphoma	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	0.0833
p.H729P	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	RRESLSYIP	DEG_APCC_DBOX_1	0.0833
p.V750L	ACH-001061	Colon/Colorectal Cancer	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	0.2222
p.R739L	ACH-001607	Gallbladder Cancer	CCLE	RRESLSYIP	DEG_APCC_DBOX_1	0.8428
p.G735E	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	RRESLSYIP	DEG_APCC_DBOX_1	0.6944
p.P734Q	NCI-H1573	lung	COSMIC	RRESLSYIP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L390	Pleckstrin homology domain-containing family G member 3	DEG_APCC_DBOX_1	738:746	RRESLSYIP	APC,CDC20,FZR1	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons