DegronMD - A6NCI8(C2orf78)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T347A	TCGA-29-1761	OV	TCGA	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1667
p.T347A	DO32207	OV	ICGC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1667
p.T347K	TCGA-29-1761	OV	TCGA	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1667
p.T347K	DO32207	OV	ICGC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1667
p.G266V	TCGA-38-4625	LUAD	TCGA	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.G266V	DO23952	LUAD	ICGC	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.E324Q	TCGA-44-2662	LUAD	TCGA	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.0556
p.E324Q	DO26290	LUAD	ICGC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.0556
p.L345F	TCGA-78-7154	LUAD	TCGA	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.2222
p.L345F	DO24070	LUAD	ICGC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.2222
p.S349F	TCGA-AX-A0J1	UCEC	TCGA	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1111
p.S349F	DO41199	UCEC	ICGC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1111
p.F311L	TCGA-B5-A1MR	UCEC	TCGA	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.587
p.F311L	DO41758	UCEC	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.587
p.A351V	TCGA-BF-AAP2	SKCM	TCGA	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.0556
p.A351V	DO219466	SKCM	ICGC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.0556
p.S316R	TCGA-BM-6198	READ	TCGA	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.2222
p.S316R	DO36978	READ	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.2222
p.S312P	TCGA-BS-A0UF	UCEC	TCGA	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.6752
p.S312P	DO41488	UCEC	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.6752
p.E252K	TCGA-D9-A148	SKCM	TCGA	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.E252K	DO37971	SKCM	ICGC	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.Q274E	TCGA-DS-A0VM	CESC	TCGA	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.Q274E	DO6258	CESC	ICGC	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.S263T	TCGA-DU-6392	LGG	TCGA	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.6005
p.S263T	DO222884	COCA	ICGC	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.6005
p.S263T	DO22237	LGG	ICGC	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.6005
p.P327S	TCGA-EE-A2GN	SKCM	TCGA	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1389
p.P327S	DO37896	SKCM	ICGC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1389
p.D333G	TCGA-EO-A3AY	UCEC	TCGA	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.3056
p.D333G	DO43202	UCEC	ICGC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.3056
p.S265C	TCGA-FD-A5BX	BLCA	TCGA	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7541
p.S265C	DO44079	BLCA	ICGC	PVSTS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7541
p.S317N	TCGA-FW-A3R5	SKCM	TCGA	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.1944
p.S317N	DO37406	SKCM	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.1944
p.P342S	DO8360	COAD	ICGC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.3056
p.P299T	DO48721	LIRI	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.1667
p.S314F	DO229459	SKCA	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.2778
p.E324D	SIDM00025	Head and Neck Carcinoma	GDSC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.0556
p.E324D	ACH-002391	Head and Neck Cancer	CCLE	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.0556
p.G295E	SIDM00120	Prostate Carcinoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.0556
p.G295E	ACH-000979	Prostate Cancer	CCLE	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.0556
p.L331F	SIDM00007	Other Solid Cancers	GDSC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.25
p.L331F	ACH-001550	Skin Cancer	CCLE	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.25
p.T308A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.7139
p.P350T	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.0833
p.P350T	ACH-000766	Lung Cancer	CCLE	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.0833
p.E310K	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.591
p.E310K	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.591
p.E310K	SIDM01682	Gastric Carcinoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.591
p.E310K	SIDM01394	Kidney Carcinoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.591
p.S312Y	SIDM00324	Neuroblastoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.712
p.S312Y	ACH-001674	Neuroblastoma	CCLE	LPQTPEFS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.712
p.S328P	SIDM01450	Gastric Carcinoma	GDSC	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1667
p.S328P	ACH-000898	Gastric Cancer	CCLE	ISITPVQS	DEG_SCF_FBW7_1	334:341	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C2orf78

UniProt ID: A6NCI8

Entrez ID: 388960

Protein name: Uncharacterized protein C2orf78

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C2orf78 in