DegronMD

Uniprot ID: A6NCI8

Source protein: Uncharacterized protein C2orf78

Source gene: C2orf78

Class: DEG_SCF_FBW7_1

Location: 334:341

E3 ligase: FBXW7

DEGRON score: 0.9659

ASA_SCORE: 78.7375

COIL: 0.8718

CONS_SCORE: 0.6137

DSS_SCORE: 0.6154

HELIX: 0.023

FCONS_SCORE: 0.9629

RIG_SCORE: 0.6896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T347A	TCGA-29-1761	OV	TCGA	ISITPVQS	DEG_SCF_FBW7_1	0.1667
p.T347A	DO32207	OV	ICGC	ISITPVQS	DEG_SCF_FBW7_1	0.1667
p.T347K	TCGA-29-1761	OV	TCGA	ISITPVQS	DEG_SCF_FBW7_1	0.1667
p.T347K	DO32207	OV	ICGC	ISITPVQS	DEG_SCF_FBW7_1	0.1667
p.E324Q	TCGA-44-2662	LUAD	TCGA	ISITPVQS	DEG_SCF_FBW7_1	0.0556
p.E324Q	DO26290	LUAD	ICGC	ISITPVQS	DEG_SCF_FBW7_1	0.0556
p.L345F	TCGA-78-7154	LUAD	TCGA	ISITPVQS	DEG_SCF_FBW7_1	0.2222
p.L345F	DO24070	LUAD	ICGC	ISITPVQS	DEG_SCF_FBW7_1	0.2222
p.S349F	TCGA-AX-A0J1	UCEC	TCGA	ISITPVQS	DEG_SCF_FBW7_1	0.1111
p.S349F	DO41199	UCEC	ICGC	ISITPVQS	DEG_SCF_FBW7_1	0.1111
p.A351V	TCGA-BF-AAP2	SKCM	TCGA	ISITPVQS	DEG_SCF_FBW7_1	0.0556
p.A351V	DO219466	SKCM	ICGC	ISITPVQS	DEG_SCF_FBW7_1	0.0556
p.P327S	TCGA-EE-A2GN	SKCM	TCGA	ISITPVQS	DEG_SCF_FBW7_1	0.1389
p.P327S	DO37896	SKCM	ICGC	ISITPVQS	DEG_SCF_FBW7_1	0.1389
p.D333G	TCGA-EO-A3AY	UCEC	TCGA	ISITPVQS	DEG_SCF_FBW7_1	0.3056
p.D333G	DO43202	UCEC	ICGC	ISITPVQS	DEG_SCF_FBW7_1	0.3056
p.P342S	DO8360	COAD	ICGC	ISITPVQS	DEG_SCF_FBW7_1	0.3056
p.E324D	SIDM00025	Head and Neck Carcinoma	GDSC	ISITPVQS	DEG_SCF_FBW7_1	0.0556
p.E324D	ACH-002391	Head and Neck Cancer	CCLE	ISITPVQS	DEG_SCF_FBW7_1	0.0556
p.L331F	SIDM00007	Other Solid Cancers	GDSC	ISITPVQS	DEG_SCF_FBW7_1	0.25
p.L331F	ACH-001550	Skin Cancer	CCLE	ISITPVQS	DEG_SCF_FBW7_1	0.25
p.P350T	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	ISITPVQS	DEG_SCF_FBW7_1	0.0833
p.P350T	ACH-000766	Lung Cancer	CCLE	ISITPVQS	DEG_SCF_FBW7_1	0.0833
p.S328P	SIDM01450	Gastric Carcinoma	GDSC	ISITPVQS	DEG_SCF_FBW7_1	0.1667
p.S328P	ACH-000898	Gastric Cancer	CCLE	ISITPVQS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NCI8	Uncharacterized protein C2orf78	DEG_SCF_FBW7_1	334:341	ISITPVQS	FBXW7	0.9659	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons