DegronMD

Uniprot ID: A6NCI8

Source protein: Uncharacterized protein C2orf78

Source gene: C2orf78

Class: DEG_SCF_FBW7_1

Location: 305:312

E3 ligase: FBXW7

DEGRON score: 0.9764

ASA_SCORE: 75

COIL: 0.8704

CONS_SCORE: 0.6794

DSS_SCORE: 0.5337

HELIX: 0.0855

FCONS_SCORE: 1.1207

RIG_SCORE: 0.7137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F311L	TCGA-B5-A1MR	UCEC	TCGA	LPQTPEFS	DEG_SCF_FBW7_1	0.587
p.F311L	DO41758	UCEC	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	0.587
p.S316R	TCGA-BM-6198	READ	TCGA	LPQTPEFS	DEG_SCF_FBW7_1	0.2222
p.S316R	DO36978	READ	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	0.2222
p.S312P	TCGA-BS-A0UF	UCEC	TCGA	LPQTPEFS	DEG_SCF_FBW7_1	0.6752
p.S312P	DO41488	UCEC	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	0.6752
p.S317N	TCGA-FW-A3R5	SKCM	TCGA	LPQTPEFS	DEG_SCF_FBW7_1	0.1944
p.S317N	DO37406	SKCM	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	0.1944
p.P299T	DO48721	LIRI	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	0.1667
p.S314F	DO229459	SKCA	ICGC	LPQTPEFS	DEG_SCF_FBW7_1	0.2778
p.G295E	SIDM00120	Prostate Carcinoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	0.0556
p.G295E	ACH-000979	Prostate Cancer	CCLE	LPQTPEFS	DEG_SCF_FBW7_1	0.0556
p.T308A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	0.7139
p.E310K	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	0.591
p.E310K	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	0.591
p.E310K	SIDM01682	Gastric Carcinoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	0.591
p.E310K	SIDM01394	Kidney Carcinoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	0.591
p.S312Y	SIDM00324	Neuroblastoma	GDSC	LPQTPEFS	DEG_SCF_FBW7_1	0.712
p.S312Y	ACH-001674	Neuroblastoma	CCLE	LPQTPEFS	DEG_SCF_FBW7_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NCI8	Uncharacterized protein C2orf78	DEG_SCF_FBW7_1	305:312	LPQTPEFS	FBXW7	0.9764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons