DegronMD - Q6XZF7(DNMBP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P623H	TCGA-A6-3809	COAD	TCGA	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.2778
p.P623H	TCGA-A6-3809	COAD	TCGA	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.3056
p.P623H	DO8722	COAD	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.2778
p.P623H	DO8722	COAD	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.3056
p.R1277W	TCGA-AA-A010	COAD	TCGA	ARKPLLGLP	DEG_APCC_DBOX_1	1259:1267	Mutation rewiring degron network	0.0556
p.Q629H	TCGA-B5-A11E	UCEC	TCGA	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.1111
p.Q629H	TCGA-B5-A11E	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1389
p.Q629H	DO41644	UCEC	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.1111
p.Q629H	DO41644	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1389
p.P615S	TCGA-BF-A3DL	SKCM	TCGA	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation altering degron motif	0.6752
p.P615S	DO51238	SKCM	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation altering degron motif	0.6752
p.R614C	TCGA-C5-A1M8	CESC	TCGA	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.3056
p.R614C	TCGA-C5-A1M8	CESC	TCGA	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2222
p.R614C	DO48993	CESC	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.3056
p.R614C	DO48993	CESC	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2222
p.P618L	TCGA-DD-AADG	LIHC	TCGA	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation altering degron motif	0.7582
p.P618L	TCGA-DD-AADG	LIHC	TCGA	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation altering degron motif	0.7582
p.P618L	DO219571	LIHC	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation altering degron motif	0.7582
p.P618L	DO219571	LIHC	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation altering degron motif	0.7582
p.K606N	TCGA-ER-A19T	SKCM	TCGA	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation substituting flanking lysine	0.1944
p.K606N	DO51251	SKCM	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation substituting flanking lysine	0.1944
p.P612A	DO223407	CLLE	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.25
p.P612A	DO223407	CLLE	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1667
p.F620L	DO8730	COAD	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation altering degron motif	0.6981
p.F620L	DO8730	COAD	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation altering degron motif	0.6981
p.P611L	DO233613	GACA	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.2222
p.P611L	DO233613	GACA	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1389
p.P611L	DO220906	MELA	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.2222
p.P611L	DO220906	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1389
p.L1266M	DO233898	GACA	ICGC	ARKPLLGLP	DEG_APCC_DBOX_1	1259:1267	Mutation altering degron motif	0.5999
p.P1267T	DO228976	LICA	ICGC	ARKPLLGLP	DEG_APCC_DBOX_1	1259:1267	Mutation altering degron motif	0.5919
p.P1267T	DO229015	LICA	ICGC	ARKPLLGLP	DEG_APCC_DBOX_1	1259:1267	Mutation altering degron motif	0.5919
p.P1431T	DO229032	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	1438:1442	Mutation rewiring degron network	0.1389
p.Y223C	DO26469	LUSC	ICGC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.25
p.Y223C	DO50118	STAD	ICGC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.25
p.S230N	DO219195	LUSC	ICGC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation altering degron motif	0.7069
p.T630I	DO220879	MELA	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.0833
p.T630I	DO220879	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1111
p.P611S	DO220906	MELA	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.2222
p.P611S	DO220906	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1389
p.S236F	DO222875	MELA	ICGC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.2222
p.S236F	DO37991	SKCM	ICGC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.2222
p.P623L	DO229502	SKCA	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.2778
p.P623L	DO229502	SKCA	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.3056
p.S611Y	DO41361	UCEC	ICGC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.2222
p.S611Y	DO41361	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1389
p.I221V	SIDM00798	Rhabdomyosarcoma	GDSC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.1944
p.I221V	ACH-000201	Rhabdoid	CCLE	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.1944
p.I221V	ACH-001212	Rhabdoid	CCLE	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.1944
p.I221V	A204	soft tissue	COSMIC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.1944
p.P613L	SIDM00928	Breast Carcinoma	GDSC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.2778
p.P613L	SIDM00928	Breast Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1944
p.P613L	CAL-85-1	breast	COSMIC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.2778
p.P613L	CAL-85-1	breast	COSMIC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1944
p.R1445M	SIDM00238	Ovarian Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	1438:1442	Mutation rewiring degron network	0.25
p.R1445M	ACH-000947	Ovarian Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	1438:1442	Mutation rewiring degron network	0.25
p.R1445M	OVK-18	ovary	COSMIC	PDSTS	DEG_SPOP_SBC_1	1438:1442	Mutation rewiring degron network	0.25
p.E241K	SIDM01059	Melanoma	GDSC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0833
p.E241K	ACH-000915	Skin Cancer	CCLE	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0833
p.E241K	IPC-298	skin	COSMIC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0833
p.P612L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.25
p.P612L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1667
p.R614H	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PCTPVST	DEG_SCF_FBW7_1	615:621	Mutation rewiring degron network	0.3056
p.R614H	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2222
p.N226D	K2	skin	COSMIC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation altering degron motif	0.6932
p.R216C	AN3-CA	endometrium	COSMIC	VDTPVGE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNMBP

UniProt ID: Q6XZF7

Entrez ID: 23268

Protein name: Dynamin-binding protein (Scaffold protein Tuba)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNMBP in