DegronMD

Uniprot ID: Q6XZF7

Source protein: Dynamin-binding protein

Source gene: DNMBP

Class: DEG_SPOP_SBC_1

Location: 1438:1442

E3 ligase: SPOP

DEGRON score: 0.8768

ASA_SCORE: 68.76

COIL: 0.8274

CONS_SCORE: 0.2205

DSS_SCORE: 0.8019

HELIX: 0.1256

FCONS_SCORE: 0.877

RIG_SCORE: 0.4985

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1445M	SIDM00238	Ovarian Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	0.25
p.R1445M	ACH-000947	Ovarian Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	0.25
p.R1445M	OVK-18	ovary	COSMIC	PDSTS	DEG_SPOP_SBC_1	0.25
p.P1431T	DO229032	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1389

Showing 1 to 4 of 4 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2J4	Angiomotin-like protein 2	DEG_SPOP_SBC_1	734:738	PDSTS	SPOP	0.9907	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	95:99	PDSTS	SPOP	0.8253	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	692:696	PDSTS	SPOP	0.9972	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	1438:1442	PDSTS	SPOP	0.8768	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	203:207	PDSTS	SPOP	0.9977	More...
O95613	Pericentrin	DEG_SPOP_SBC_1	3322:3326	PDSTS	SPOP	0.978	More...
Q96SK2	Transmembrane protein 209	DEG_SPOP_SBC_1	261:265	PDSTS	SPOP	0.9778	More...
Q8N446	Zinc finger protein 843	DEG_SPOP_SBC_1	190:194	PDSTS	SPOP	0.8804	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SPOP_SBC_1	615:619	PDSTS	SPOP	0.585	More...

Showing 1 to 9 of 9 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons