DegronMD

Uniprot ID: Q96SK2

Source protein: Transmembrane protein 209

Source gene: TMEM209

Class: DEG_SPOP_SBC_1

Location: 261:265

E3 ligase: SPOP

DEGRON score: 0.9778

ASA_SCORE: 83.12

COIL: 0.9522

CONS_SCORE: 0.3419

DSS_SCORE: 0.5661

HELIX: 0.0304

FCONS_SCORE: 1.0066

RIG_SCORE: 0.5508

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G259E	TCGA-ER-A198	SKCM	TCGA	PDSTS	DEG_SPOP_SBC_1	0.2778
p.G259E	DO47563	SKCM	ICGC	PDSTS	DEG_SPOP_SBC_1	0.2778
p.P266L	TCGA-GF-A6C9	SKCM	TCGA	PDSTS	DEG_SPOP_SBC_1	0.3056
p.P266L	DO51254	SKCM	ICGC	PDSTS	DEG_SPOP_SBC_1	0.3056
p.Y275C	DO222364	BTCA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.0556
p.D262Y	DO233876	GACA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.6214
p.T271N	DO228971	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1667
p.S260R	DO229029	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.75
p.S268R	DO229026	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.25
p.S268G	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	0.25
p.S268G	ACH-000627	Lung Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	0.25
p.S268G	LCLC-103H	lung	COSMIC	PDSTS	DEG_SPOP_SBC_1	0.25
p.S267G	LCLC-103H	lung	COSMIC	PDSTS	DEG_SPOP_SBC_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	DEG_SPOP_SBC_1	3322:3326	PDSTS	SPOP	0.978	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	203:207	PDSTS	SPOP	0.9977	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	1438:1442	PDSTS	SPOP	0.8768	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	692:696	PDSTS	SPOP	0.9972	More...
Q9Y2J4	Angiomotin-like protein 2	DEG_SPOP_SBC_1	734:738	PDSTS	SPOP	0.9907	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SPOP_SBC_1	615:619	PDSTS	SPOP	0.585	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	95:99	PDSTS	SPOP	0.8253	More...
Q96SK2	Transmembrane protein 209	DEG_SPOP_SBC_1	261:265	PDSTS	SPOP	0.9778	More...
Q8N446	Zinc finger protein 843	DEG_SPOP_SBC_1	190:194	PDSTS	SPOP	0.8804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons