DegronMD

Uniprot ID: Q8N446

Source protein: Zinc finger protein 843

Source gene: ZNF843

Class: DEG_SPOP_SBC_1

Location: 190:194

E3 ligase: SPOP

DEGRON score: 0.8804

ASA_SCORE: 67.6

COIL: 0.657

CONS_SCORE: 0

DSS_SCORE: 0.5734

HELIX: 0.0228

FCONS_SCORE: 0

RIG_SCORE: 0.6131

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G203R	TCGA-A2-A04V	BRCA	TCGA	PDSTS	DEG_SPOP_SBC_1	0.0833
p.G203R	DO1532	BRCA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.0833
p.G203R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	0.0833
p.A189T	TCGA-AA-A01P	COAD	TCGA	PDSTS	DEG_SPOP_SBC_1	0.3056
p.A189T	DO8642	COAD	ICGC	PDSTS	DEG_SPOP_SBC_1	0.3056
p.L196I	TCGA-FI-A2D5	UCEC	TCGA	PDSTS	DEG_SPOP_SBC_1	0.2778
p.L196I	DO41331	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	0.2778
p.S194Y	DO227987	COCA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.712
p.G200E	DO233207	GACA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1667
p.S182R	DO228948	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1111
p.P185T	DO228952	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1944
p.R197W	SIDM02074	Esophageal Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	0.25
p.R197W	ACH-000941	Endometrial/Uterine Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	0.25
p.R197W	ACH-000954	Endometrial/Uterine Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	0.25
p.R197W	ACH-001517	Endometrial/Uterine Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	DEG_SPOP_SBC_1	3322:3326	PDSTS	SPOP	0.978	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	203:207	PDSTS	SPOP	0.9977	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	1438:1442	PDSTS	SPOP	0.8768	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	692:696	PDSTS	SPOP	0.9972	More...
Q9Y2J4	Angiomotin-like protein 2	DEG_SPOP_SBC_1	734:738	PDSTS	SPOP	0.9907	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SPOP_SBC_1	615:619	PDSTS	SPOP	0.585	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	95:99	PDSTS	SPOP	0.8253	More...
Q96SK2	Transmembrane protein 209	DEG_SPOP_SBC_1	261:265	PDSTS	SPOP	0.9778	More...
Q8N446	Zinc finger protein 843	DEG_SPOP_SBC_1	190:194	PDSTS	SPOP	0.8804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons